Clinical Core

项目总结-临床核心（核心C） 拟议的临床核心（核心C）将支持埃默里尤德尔中心的项目4，在其研究的跨- 前额叶皮层和丘脑底核之间在反应抑制功能中的作用， 接受脑深部电刺激（DBS）电极导线植入手术的帕金森病（PD）患者 瞄准了敌人。前额叶皮层在PD相关的认知和行为变化中起着核心作用， 特别是在执行功能中，例如反应抑制。核心小组将提供协调员服务， 项目四研究。除了研究活动，完成的评估文件，和协调， 在完成详细的认知评估后，核心关注患者招募和保留 战略布局核心将利用Emory的DBS项目招募特征良好的PD患者 正在进行DBS选择过程（目标1）的患者，目标是招募40名此类患者， 手术评估，包括详细的神经心理学测试和运动评估， 将在项目4下完成的反应抑制任务期间进行测试。招聘活动将包括 通过在诊所分发传单、网络和社交媒体广告的各种广告策略，以及 作为公开展示。在招募的PD患者中，15名患者还将在DBS电极导线植入期间在手术室接受测试。 20名患者将在术后6-12个月进行重复门诊评估。此外，核心将 招募40名特征良好的年龄和性别匹配的健康对照，通过与各种现有的 来源，包括埃默里阿尔茨海默病研究中心（ADRC）的临床核心，和埃默里 健康大脑研究（目标2）。这些个体将在访视1时接受与PD队列相同的一系列检查。 为了确保连续性，所有神经心理学评估将由Udall中心的Co-Is之一监督 同时也是美国抗抑郁症研究委员会临床核心的共同领导人核心将传达个人的结果 并向所有研究参与者发送分组测试结果。最后，核心将开发和维护一个REDCap数据库 项目4（目标3）收集的数据。

Project Summary – Clinical Core (Core C) The proposed Clinical Core (Core C) will support project 4 of the Emory Udall Center in its studies of the inter- actions between the prefrontal cortex and the subthalamic nucleus (STN) in response inhibition functions in patients with Parkinson’s disease (PD) who undergo deep brain stimulation (DBS) lead implantation procedures targeting the STN. The prefrontal cortex plays a central role in PD-associated cognitive and behavioral changes, particularly in executive functions, such as response inhibition. The Core will provide coordinator services for the project 4 studies. In addition to research activity, documentation of completed assessments, and coordinat- ing the completion of detailed cognitive assessments, the Core focuses on patient recruitment and retention strategies. The Core will leverage the active DBS program at Emory to recruit well-characterized PD patients who are undertaking the DBS selection process (Aim 1), with the goal of recruiting 40 such patients for pre- operative assessments, including detailed neuropsychological testing and motor evaluations in addition to the testing during response inhibition tasks that will be done under project 4. Recruitment activities will include various advertising strategies through flyers distributed in the clinic, web and social media advertising, as well as public presentations. Of the recruited PD patients, 15 will also be tested in the OR during DBS lead implan- tation, and 20 will have a repeat outpatient assessment 6-12 months post-surgery. In addition, the Core will recruit 40 well-characterized age- and sex-matched healthy controls through a collaboration with various existing sources, including the Clinical Core of the Emory Alzheimer’s Disease Research Center (ADRC), and the Emory Healthy Brain Study (Aim 2). These individuals will undergo the same series of tests as the PD cohort at visit 1. To ensure continuity, all neuropsychological assessments will be overseen by one of the Udall Center’s Co-Is who also functions as co-leader of the ADRC clinical core. The Core will communicate the results of individual and group test results to all study participants. Finally, the Core will develop and maintain a REDCap database of data collected in project 4 (Aim 3).