In-situ & operando organic electrochemical transistors monitored by non-destructive spectroscopies for organic CMOS-like neuromorphic circuits (ICONIC)

超柔性、舒适和可植入的人工智能有机电子设备有望彻底改变慢性疾病的实时监测和治疗。这种器件基于有机电化学晶体管（OECT），其利用聚合物混合离子-电子导体（PMIEC）作为活性层。然而，有效和稳定的设备的发展受到阻碍有限的知识PMIEC的结构-性能关系。ICONIC以创新的方式将大分子合成与原位和操作性非破坏性光谱方法相结合，以前所未有的精度研究OECTs中从分子到微米尺度的离子到电子的转导。这为智能治疗设备的发展提供了技术飞跃的关键知识。作为概念验证，ICONIC开发了一种用于药物输送激活的智能闭环设备。从长远来看，医疗设备将能够通过对身体友好的电子设备进行信号识别，并在没有人为错误风险的情况下进行药物管理。ICONIC是一个多学科的高风险/高收益项目，涉及来自6个国家的8个合作伙伴，涵盖学术界和工业界（包括1个中小企业）。通过4个工作包（3个技术工作包）促进执行工作。合作伙伴和利益相关者带来的互补科学技能最大限度地发挥了ICONIC的影响力。

Ultra-flexible, conformable and implantable artificial intelligence organic electronic devices hold promise to revolutionize the realtime monitoring and treatment of chronic diseases. Such devices are based on organic electrochemical transistors (OECTs) exploiting polymeric mixed ion-to-electron conductors (PMIECs) as active layers. However, the development of efficient and stable devices is hindered by limited knowledge about structure-property relationships of PMIECs. ICONIC combines macromolecular synthesis with in situ and operando non-destructive spectroscopic methods in an innovative way to investigate with unprecedented accuracy ion-toelectron transduction in OECTs, from the molecular to the micrometre scale. This provides the key knowledge to make a technological leap in development of smart therapeutic devices. As a proof of concept, ICONIC develops an intelligent closed-loop device for drug delivery activation. In a long-term vision, healthcare devices will enable signal recognition with body-friendly electronics and administer medication without the risk of human error. ICONIC is a multidisciplinary high-risk/high-gain project engaging 8 partners from 6 countries covering the academic and industrial worlds (including 1 SME). The implementation is facilitated through 4 work packages (3 technical). The complementary scientific skills brought in by the partners and stakeholders maximizes ICONIC’s impact.