Understanding the mechanisms of class B GPCR-transducer coupling

目前针对G蛋白偶联受体（gpcr）的药物开发由于缺乏对受体功能的复杂性和时空控制的理解，往往导致成功率低。该研究项目旨在了解受体/换能器选择性的分子机制。该提案整合了多学科方法，以提供对受体如何响应不同配体被激活的更深层次的理解。预期的结果包括提高理解基础生物学的能力，加强国家和国际合作。这将提供显著的好处，包括扩大基础知识和提高药物开发效率。

Current effort in developing drugs targeting G protein-coupled receptors (GPCRs) often result in low success rate due to the lack of understanding of the complexity and the spatiotemporal control of receptor function. The research program aims to understand the molecular mechanisms of receptor/transducer selectivity. The proposal integrated multi-disciplinary approaches to provide a deeper understanding of how the receptor is activated responding to different ligands. The anticipated outcome including an enhanced capacity for understanding the fundamental biology, a stronger national and international collaborations. This will provide significant benefits including expanded basic knowledge and improvements in drug development efficiency.