High Throughput Platform for the Discovery of GMP Compatible Stem Cell Manufacturing Protocols

以受控和可再生的方式制造细胞是再生医学的关键挑战。我们将开发一种集成平台技术，用于快速识别新型、高效的干细胞扩增和分化方案，这些方案经过优化，可用于临床级生产。将结合几种创新技术进行高通量GMP兼容筛选，以发现新的细胞生产方案。这些方案将被转移到一个规模扩大的生物过程中，其中一种新的细胞成像技术将被用来监测细胞性能。成功的方案将转化为GMP生产工艺进行最终验证。通过这种方式，将快速发现安全，稳健，具有成本效益的GMP验证方案，大大降低再生细胞疗法开发的成本和时间。

The manufacture of cells in a controlled and reproducible manner is a critical challenge in regenerative medicine. We will develop an integrated platform technology for the rapid identification of novel, efficient stem cell expansion and differentiation protocols that are optimised for translation to clinical grade manufacturing. Several innovative technologies will be combined to perform high throughput GMP compatible screens to discover novel cell production protocols. These protocols will be transferred to a scaled-up bioprocess where a novel cell imaging technology will be utilised to monitor cell performance. Successful protocols will be translated to a GMP manufacturing process for final validation. In this way, safe, robust, cost-effective GMP validated protocols will be rapidly discovered, greatly reducing the cost and time for development of regenerative cell therapeutics.