Safe and Sustainable by Design framework for the next generation of Chemicals and Materials

SSbD4ChEM将来自工业界、政府、学术界和民间社会的利益相关者聚集在一起，通过3个案例研究的示范，开发和推广安全和可持续的产品和工艺设计的最佳实践。SSbD4CheM旨在通过开发全面的安全和可持续的按设计(SSbD)框架来实现欧盟在数字、使能和新兴技术、部门和价值链方面的战略目标，该框架使用基于科学的新方法来识别和解决潜在的危险和风险，并通过创新技术支持更安全和更可持续的产品和流程的设计。SSbD4CheM的目标包括：1)SSbD框架，以促进适用于汽车价值链中可再生复合材料的下一代化学品和材料的开发，用于纺织品和纤维素纳米纤维的无PFAS涂层作为化妆品中的添加剂以取代塑料微珠，2)开发用于替代评估下一代化学品/材料/产品的高效危险筛选工具，结合硅工具和多标准分析，3)由分子和数据驱动的建模支持的高级探索性事前LCA方法，以填补(新型)材料和化学品的数据空白，4)整合化学/(纳米)材料表征方法以评估产品的环境安全，量化排放以支持职业和消费者安全限度，5)开发替代的体外模型，作为充分暴露情景的新方法的一部分；6)协调和验证分析和毒理学方法，以便向监管和标准化机构提出建议，以促进新标准的制定和促进市场对SSbD4CheM项目结果的接受；以及7)通过利益攸关方的参与、培训、传播和利用，提高SSbD4CheM的整体影响，并推动产业创新。

SSbD4ChEM brings together stakeholders from industry, government, academia, and civil society to develop and promote best practices for safe and sustainable product and process design, through demonstration in 3 case studies. SSbD4CheM aims to meet the EU's strategic objectives for digital, enabling, and emerging technologies, sectors, and value chains by developing a comprehensive Safe and Sustainable by Design (SSbD) framework that uses new science-based approaches to identify and address potential hazards and risks, and innovative technologies to support the design of safer and more sustainable products and processes. SSbD4CheM objectives include: 1) SSbD framework to facilitate development of the next generation of chemicals and materials applicable to renewable composites in automotive value chain, PFAS-free coatings for textile and cellulose nanofibers as additive in cosmetics to replace plastic microbeads, 2) Development of efficient hazard screening tools for alternative assessment of next generation chemicals/materials/products combining in silico tools and multicriteria analysis, 3) Advanced explorative ex-ante LCA method supported by molecular and data-driven modelling to fill data gaps for (novel) materials and chemicals, 4) Integration of chemical/(nano-)material characterization methods to assess products’ environmental safety, quantify emissions to support occupational and consumer safety limits, 5) Development of alternative, in vitro models, as part of New Approach Methodologies for adequate exposure scenarios, 6) Harmonization and validation of analytical and toxicological methods for proposition to regulatory and standardization bodies to contribute to the development of new standards and facilitate market acceptance of SSbD4CheM project results, and 7) Enhance overall SSbD4CheM impact through stakeholder engagement, training, dissemination and exploitation and drive industrial innovation.