An Integrated Life-course Approach for Person-centred Solutions and Care for Ageing with Multi-morbidity in the European Regions - STAGE; Stay Healthy Through Ageing

这一阶段的目的是证明采用终生方法预防多种疾病累积所界定的加速老龄化的重要性和可行性，并将知识纳入可转让的以人为本的解决方案，以便对多种疾病进行早期诊断和筛查、治疗和长期管理。为了实现这一目标，Stage正在提出一种生命过程方法，以更好地理解患有多种疾病的老龄化，提供以证据为基础的解决方案，以支持医疗保健的转型，以应对未来深刻的健康和人口挑战。该方法利用欧洲合作的纵向队列和跨越整个生命过程的生物库，采取行动暴露组和疾病网络轨迹分析，以及衰老生物学，以探索一个人如何患上多种疾病的衰老。项目目标综合了伦理、社会、历史和基础设施框架；环境、流行病学和生物生命过程方法；人工智能驱动的以人为中心的综合解决方案和应用；以队列为基础的临床研究；公平(可查找、可访问、可互操作和可重复使用)的生命周期健康和地理空间数据门户，以及强有力的管理、传播、参与和开发活动。Stage的循证方法将在芬兰和德国的纵向队列中转化为以人为中心的预防和护理干预，与公民、患者、医疗保健提供者、中小企业和政策制定者共同设计。它还将嵌入社会科学和人文科学，并让利益攸关方参与制定邻里健康老龄化指数、以人为中心的多种疾病预测以及医疗保健和政策建议。最终，Stage将为灵活、高质量、以人为本的健康和护理服务创造解决方案，这些服务对生命过程和性别敏感、基于需求，旨在提高复原力和参与度。

STAGE aims to demonstrate the importance and feasibility of a life-course approach to prevent accelerated ageing, as defined by the accumulation of multi-morbidity, and to integrate knowledge into transferable person-centred solutions for early diagnosis and screening, treatment and long-term management of multi-morbidity. To achieve this, STAGE is proposing a life-course approach to better understand ageing with multi-morbidity, providing evidence-based solutions to support the transformation of healthcare to address the profound health and demographic challenges ahead. The approach capitalises on European collaborations of longitudinal cohorts and biobanks spanning the entire life-course, actioning exposome and disease networks trajectory analysis, as well as, the biology of ageing, to explore how a person develops ageing with multi-morbidity. The project objectives integrate an ethical, social, historical, and infrastructural framework; environmental, epidemiological and biological life-course approaches; artificial intelligence powered integrated person centred solutions and applications; cohort-based clinical studies; and a FAIR (findable, accessible, interoperable and reusable) life-course health and geospatial data portal with robust management, dissemination, engagement and exploitation activities. STAGE's evidence based methods will translate into a person-centred prevention and care intervention in longitudinal cohorts in Finland and Germany, co designed with citizens, patients, healthcare providers, SMEs, and policymakers. It will also embed social sciences and humanities and engage stakeholders to develop a neighbourhood healthy ageing index, person-centred predictions of multi-morbidity, and healthcare and policy recommendations. Ultimately, STAGE will create solutions for agile, high-quality, person-centred health and care services that are life-course and gender sensitive, needs-based, and designed to enhance resilience and participation.