Core A - Clinical Database.

核心A摘要/摘要 这个核心的主要目标是招收每一位转诊到华盛顿大学的AML和MDS患者 进入GAML计划项目的组织获取和临床数据库协议。皮肤、口腔粘膜、骨骼 从患者身上收集的骨髓、外周血白细胞和血清样本将被储存和处理 由核心B，(标本数据库)，因此它们将作为核心概述的基因组分析的基础 C(测序和分析)，用于项目1-4。该临床核心还将保持和扩展 全面的数据库，包含基本的临床、病理、核型、分子、治疗和 登记的AML和MDS患者的结果数据，与相应的组织标本匿名链接。 临床核心数据库将为核心B准备的样本和基因组提供关键的临床注释 核心C开展的研究，将用于项目1-4。 具体目标/核心服务1： 我们将尝试前瞻性地登记和收集在诊断、缓解和复发时的组织 患者转诊至华盛顿大学西特曼癌症中心，患有AML和MDS。 特定目标/核心服务2： 我们将维护一个全面的临床白血病数据库，该数据库将收集流行病学数据、疾病- 所有入选的急性髓细胞白血病患者的相关特征、预后因素、治疗信息和结果数据 MDS患者，与相应的银行组织样本存在未识别的连锁。 具体目标/核心服务3： 我们将为所有PPG活动提供统计和信息学支持，包括以下项目的样本量评估 人类和老鼠研究，出版物所有数据集的详细统计评估，以及IT支持 数据库管理。

CORE A SUMMARY/ABSTRACT The main objective of this core is the enrollment of every patient AML and MDS referred to Washington University into the Tissue Acquisition and Clinical Database protocol of the GAML program project. Skin, oral mucosa, bone marrow, peripheral blood leukocytes and serum specimens collected from patients will be banked and processed by Core B, (Specimen Database), whereupon they will serve as the basis for genomic analyses outlined in Core C (Sequencing and Analysis), to be utilized in Projects 1-4. This Clinical Core will also maintain and expand a comprehensive database that captures essential clinical, pathological, karyotypic, molecular, therapeutic, and outcomes data of enrolled AML and MDS patients, anonymously linked with the corresponding tissue specimens. The Clinical Core database will provide key clinical annotation for the samples prepared by Core B, and genomic studies performed by Core C, which will be utilized by Projects 1-4. Specific Aim/Core Service 1: We will attempt to prospectively enroll and collect tissue at diagnosis, in remission, and at relapse from every patient referred to the Washington University Siteman Cancer Center with AML and MDS. Specific Aim/Core Service 2: We will maintain a comprehensive clinical leukemia database that will capture epidemiological data, disease- related characteristics, prognostic factors, therapeutic information, and outcomes data from all enrolled AML and MDS patients, with de-identified linkage to corresponding banked tissue specimens. Specific Aim/Core Service 3: We will provide statistical and informatics support for all PPG activities, including sample size assessments for human and mouse studies, detailed statistical evaluations of all datasets for publications, and IT support for database management.