Core C: Radiosensitization Core

项目摘要/摘要(放射增敏核心) 该孢子内的放射增敏核心将提供专门的专业知识、仪器和 为每个项目提供与辐射评估有关的研究活动的技术服务 治疗药物的敏化。这些服务包括对培养细胞和动物模型进行照射， 皮下和原位肿瘤适形照射治疗计划的制定 以优化联合治疗的剂量和方案为目标的影像治疗反应 以理性和机制驱动的方式。核心有三个正压单元，一个SARRP(小 动物辐射研究平台)，该平台允许生物发光和CT引导的辐射传递到 以及研究单细胞DNA修复的激光微照射仪。此外， 放射增敏核心将成为孢子调查人员获取研究资源的中央渠道 罗杰尔癌症中心，包括药代动力学共享资源和临床前成像和 计算分析共享资源。Balter博士将监督与图像引导辐射相关的活动 治疗和适形治疗计划。Rehemtulla博士将指导对小鼠癌症模型和 成像，为每个特定项目的治疗范例提供定量和机械性的见解。 利奥波德博士将监督与临床前剂量优化相关的研究，并在 告知设计每个项目中计划的临床试验的方式。放射增敏核心还将 与孢子内的其他核心、生物统计和计算生物学核心以及 翻译病理学核心，以确保进行临床前研究的规划和执行 科学严谨，并与每个项目的目标保持一致。整合了 放射增敏核心与每个研究项目和核心是关键的，并将提供孢子 研究人员能够进行对患者管理产生积极影响的研究 放射疗法。

PROJECT SUMMARY/ABSTRACT (Radiosensitization Core) The Radiosensitization Core within this SPORE will provide specialized expertise, instrumentation and technical services to each of the Projects for their research activities related to evaluation of radiation sensitization of therapeutic agents. These services include irradiation of cultured cells and animal models, development of treatment plans for conformal irradiation of subcutaneous and orthotopic tumors, evaluation of therapeutic response using imaging with the goal of optimizing dose and schedule of the combination therapies in a rational and mechanism driven manner. The Core features three orthovoltage units, a SARRP (Small Animal Radiation Research Platform) which permits bioluminescence and CT-guided delivery of radiation to animals as well a laser microirradiation instrument to study DNA repair in single cells. Additionally, the Radiosensitization Core will be a central conduit for SPORE investigators to access research resources within the Rogel Cancer Center, including the Pharmacokinetics Shared Resource and the Preclinical Imaging and Computational Analysis Shared Resource. Dr. Balter, will oversee activities related to image-guided radiation therapy and conformal treatment planning. Dr. Rehemtulla, will guide studies on mouse models of cancer and imaging to provide quantitative and mechanistic insights for each of the project-specific therapeutic paradigms. Dr. Leopold will oversee research related to preclinical optimization of dosing and schedule for test agents in a manner that informs design of the planned clinical trials in each project. The Radiosensitization Core will also work seamlessly with the other Cores within the SPORE, the Biostatistics and Computational Biology Core and the Translational Pathology Core, to ensure that the planning and execution of pre-clinical studies is conducted with scientific rigor and consistent with the goals of each of the projects. The integration of the Radiosensitization core with each of the research Projects and the Cores is critical and will provide SPORE investigators the ability to conduct studies that positively impact the management of patients undergoing radiation therapy.