The Neurobiology of Drug Abuse

药物滥用神经生物学培训方案综述 制定有效的药物使用障碍预防和治疗策略的关键之一是 了解长期接触滥用药物的神经生物学后果。这样的研究必须 涉及多学科方法，以检查几个不同水平的大脑功能。这是我们的目标 我们目前的培训计划，药物滥用的神经生物学培训计划，建议继续一个 维克森林医学院(WFSM)NIDA培训的成功传统。该程序请求 资助在药物滥用的神经生物学多学科项目中培训五名博士前学生。这个 该项目包括WFSM的24名教职员工，研究兴趣涵盖分子生物学、受体 药理学，人类和非人类灵长类的脑成像技术，电生理学，神经元 药物自我给药活动监测与行为分析。教职员工的研究是 得到了与药物滥用领域有关的大量联邦资助赠款的支持。这个 培训计划围绕三个主要研究领域组织：分子/细胞神经生物学， 神经生物学系统和行为神经生物学。培训计划提供了一门专门的毒品课程 涉及与这三个领域相关的主题的虐待。博士前学生有两个不同的选择 博士学位跟踪：综合生理学/药理学和神经科学。尽管这些计划有 他们自己的个人要求，具体的药物滥用相关主题都被纳入标准 程序。培训计划为学员提供特定的研讨会和杂志俱乐部，并为 额外的药物滥用培训。该程序还包含处理以下内容的专门组件 统计/数据分析、拨款撰写、研究的严格性和透明度以及科学研究的道德规范。 神经科学领域是增长最快的领域之一，这将有助于招收学生 在生物科学领域，密克罗尼西亚联邦正在经历一个强劲的研究增长阶段。此外, 从代表性不足的少数族裔招聘申请者将是一个高度优先事项，包括本科生。 与温斯顿·塞勒姆州立大学、北卡罗来纳农工大学和北卡罗来纳州的培训项目 中央大学。总之，药物滥用的神经生物学培训项目不仅为学生提供 在药物滥用的神经生物学方面的教育和研究机会也是宝贵的 为药物滥用领域提供资源，提供训练有素的年轻调查人员，能够独立进行科学研究 事业。

NEUROBIOLOGY OF DRUG ABUSE TRAINING PROGRAM SUMMARY One of the keys to developing effective prevention and treatment strategies for substance use disorder is understanding the neurobiological consequences of chronic exposure to drugs of abuse. Such studies must involve multi-disciplinary approaches to examine several different levels of brain function. This is the goal of our current training program, the Neurobiology of Drug Abuse Training Program, which proposes to continue a successful tradition of NIDA training at Wake Forest School of Medicine (WFSM). This program requests funding to train five predoctoral students in a multi-disciplinary program in the neurobiology of drug abuse. The program includes 24 faculty members at WFSM, with research interests spanning molecular biology, receptor pharmacology, brain imaging techniques in humans and non-human primates, electrophysiology, neuronal activity monitoring and behavioral analysis of drug self- administration. The research of the faculty is supported by a significant number of federally-funded grants related to the field of substance abuse. The training program is organized around three principal areas of research: Molecular/Cellular Neurobiology, Neurobiological Systems, and Behavioral Neurobiology. The training program offers a specific course in drug abuse covering topics related to each of these three areas. Predoctoral students have a choice of two different Ph.D. degree tracks: Integrated Physiology/Pharmacology and Neuroscience. Although these programs have their own individual requirements, specific drug abuse-related topics are integrated into the standard programs. The training program offers specific seminars and journal clubs for trainees and opportunities for additional substance abuse training. The program also contains specialized components dealing with statistics/data analytics, grant writing, rigor and transparency in research, and ethics in scientific research. Recruitment of students will be aided by the fact that the field of neuroscience is one of the fastest growing disciplines in the biological sciences, and WFSM is undergoing a strong research growth phase. In addition, recruitment of applicants from under- represented minorities will be a high priority, including undergraduate training programs with Winston Salem State University, North Carolina A&T University and North Carolina Central University. In summary, the Neurobiology of Drug Abuse Training Program not only offers students outstanding opportunities for education and research in the neurobiology of drug abuse but is also a valuable resource for the field of drug abuse by providing trained young investigators capable of independent scientific careers.