Validating a machine learning model of eye tracking in children with cortical visual impairment (CVI)

项目总结 皮质视力损害(CVI)是发达国家儿童视力损害的主要原因。那里 没有循证治疗，临床试验的设计因缺乏有效的方法而受阻 视觉评估，捕捉了儿科患者视觉功能受损的许多方面 CVI。我们的实验室正在研究眼球跟踪技术在CVI儿童中的应用。在眼睛跟踪过程中，红外线 当孩子在电脑上观看视觉刺激时，相机会跟踪瞳孔和角膜的光线反射 监视器。眼睛跟踪器计算眼睛注视的方向，具有很高的空间和时间频率。我们的眼睛 跟踪协议在12分钟内评估多个传入、传出和更高阶视参数 录制会话。我们的初步数据显示，眼球跟踪是可靠的，可以量化多种视觉和眼球运动 CVI患儿的相关参数。考虑到眼睛跟踪产生的大量数据(2,000个数据点 每秒)，则需要更高级别的分析。我们将验证眼睛跟踪的机器学习模型 CVI儿童通过三个具体目标。在目标1中，我们将量化儿童CVI的视觉功能缺陷。 使用眼球跟踪，通过包含一个强大的样本来加强我们初步数据中的发现。在……里面 目标2，我们将使用机器学习来开发CVI眼球跟踪严重程度评分。在目标3中，我们将验证眼睛 儿童CVI、SWEEP与其他两种视觉评估方法的追踪比较 视觉诱发电位和CVI范围。总之，这些研究将把眼球跟踪作为一种量化的、 目的、全面测量儿童CVI的视功能。在计划的R01应用程序中 K23奖励期结束后，我们将纳入CVI眼球跟踪严重程度评分，作为 标准和靶向治疗CVI的纵向研究。为了追求这些目标，我将得到一位 洛杉矶儿童医院经验丰富、跨学科、国际公认的团队 南加州大学。在他们的指导下，我还将攻读应用数据硕士学位 科学，并获得电生理学的经验学习。在我的职业生涯中获得的培训 发展奖将使我能够过渡到领导研究项目的独立调查员 专注于开发下一代技术来询问患有各种疾病的儿童的视觉系统 神经发育障碍。

Project summary Cortical visual impairment (CVI) is the leading cause of pediatric visual impairment in developed countries. There is no evidence-based treatment, and design of clinical trials is hampered by the absence of a validated method of visual assessment that captures the numerous aspects of visual function that are compromised in pediatric CVI. Our laboratory is investigating the use of eye tracking in children with CVI. During eye tracking, an infrared camera tracks the pupillary and corneal light reflections while a child watches visual stimuli on a computer monitor. The eye tracker calculates the direction of eye gaze with high spatial and temporal frequency. Our eye tracking protocol assesses multiple afferent, efferent, and higher-order visual parameters during a 12-minute recording session. Our initial data show that eye tracking is reliable and quantifies multiple visual and oculomotor parameters in children with CVI. Given the large amount of data generated by eye tracking (2,000 data points per second), higher-level analytics are required. We will validate a machine-learning model of eye tracking in children with CVI via three Specific Aims. In Aim 1, we will quantify deficits of visual function in pediatric CVI using eye tracking, strengthening the findings in our preliminary data by inclusion of a well-powered sample. In Aim 2, we will use machine learning to develop a CVI eye tracking severity score. In Aim 3, we will validate eye tracking by comparing and contrasting with two other methods of visual assessment in children with CVI, sweep visual evoked potentials and the CVI Range. Together, these studies will establish eye tracking as a quantitative, objective, and comprehensive measure of visual function in pediatric CVI. In the R01 application planned at the end of the K23 award period, we will incorporate the CVI eye tracking severity score as an outcome measure in a longitudinal study of standard and targeted therapies for CVI. In pursuit of these aims, I will be mentored by a highly experienced, interdisciplinary, internationally recognized team at Children’s Hospital Los Angeles and University of Southern California. Under their guidance, I will also pursue a Masters degree in Applied Data Science and gain experiential learning in electrophysiology. The training acquired during my Career Development Award will enable me to transition to an independent investigator leading a research program focused on developing next-generation technologies to interrogate the visual system in children with a variety of neurodevelopmental disorders.