CAR Therapy for T Cell Malignancies

t细胞是我们体内的免疫细胞，其功能是“寻找并摧毁”被病毒感染的细胞。由于t细胞积极地在我们的身体周围移动，寻找被感染的细胞，医学科学长期以来一直试图让这些t细胞攻击癌细胞。因为癌细胞通常来自我们体内没有病毒感染的正常细胞，所以t细胞通常不会攻击它们。通过从血液样本中提取t细胞并使用基因工程对其进行“重新编程”，医学科学已经找到了一种利用t细胞攻击癌症的方法。这些经过改造的t细胞被称为“CAR - t细胞”，它们可以作为点滴注入病人体内。一旦回到病人体内，它们就会“寻找并摧毁”癌细胞，就好像它们是被病毒感染的细胞一样。CAR - t细胞似乎是一种非常有效的新型癌症治疗方法。癌症可以来自我们体内的任何细胞。event细胞可以变成癌细胞，其中一些癌症被称为t细胞淋巴瘤。这个项目处理CAR - t细胞攻击t细胞淋巴瘤的特殊问题。从事这个项目的科学家们已经找到了一种制造CAR - t细胞的方法，这种细胞可以攻击癌变的t细胞，但不影响大量正常的健康t细胞。

T-cells are immune cells in our bodies whose function is to "seek and destroy" cells which are infected byviruses. Since T-cells actively move around our bodies looking for infected cells, medical science has long triedto make these T-cells attack cancer cells. Because cancer cells usually come from normal cells in our bodieswithout virus infections, T-cells don't normally attack them. By taking T-cells from a blood sample and "re-programming" them using genetic engineering, medical science has found a way of using T-cells to attackcancer. These engineered T-cells are called "CAR T-cells" and they can be given back to the patient as a drip.Once back in the patient, they "seek and destroy" cancer cells as if they were virus-infected cells. CAR T-cellsseem to be a very effective new form of cancer treatment. Cancers can come from any cells in our bodies. EvenT-cells can become cancer cells and some of these cancers are called T-cell lymphomas. This project deals withthe particular problem of CAR T-cells attacking T-cell lymphomas. Scientists working on this project have founda way of making CAR T-cells that attack the cancerous T-cells but leave plenty of normal healthy T-cells alone.