AXIAL FLOW BLOOD PUMP WITH SIMPLIFIED BEARINGS

近年来心室辅助装置（VAD）技术的进展 十年来，人们在很大程度上局限于为成年人设计的概念。 人口 儿科患者的机械支持选择 严重的心力衰竭，尤其是那些等待心脏 移植是非常有限的。 使用的主要限制 目前可用于儿科心脏搭桥的VAD 移植是这些装置的过大尺寸。 设备 需要专门用于满足特殊尺寸和 儿科人群的血流动力学要求。 为此， Nimbus公司以及它的发展伙伴匹兹堡大学， 利用了他们在轴流方面的集体经验， 离心血泵技术，VAD在临床环境中的使用， 和小儿心脏移植来设计一个原型， VAD适合植入儿科老年患者。 的目的 这一拟议的第一阶段SBIR计划将通过体外试验证明， 性能测试和体内植入的可行性，这 创新设计，用于儿科移植桥循环支持。 如果最终成功，这种泵将具有商业应用， 在美国和国外的医院销售的产品。 建议的商业应用：本研究的最终结果 作为产品在美国的医院销售的商业应用， 国外 大约10%-20%的先天性心脏病患者存活 缺陷可以进行心脏移植。

Advances in ventricular assist device (VAD) technology during the last decade have been largely limited to concepts intended for the adult population. Options for mechanical support of pediatric patients with severe heart failure, and especially those who are awaiting cardiac transplantation, are extremely limited. The primary limitation to the use of currently available VADs for pediatric bridging-to-cardiac transplantation is the excessive size of these devices. Devices are needed that are specifically intended to meet the special size and hemodynamic requirements of the pediatric population. To that end, Nimbus, Inc. and its development partner, the University of Pittsburgh, have capitalized on their collective experience in axial flow and centrifugal blood pump technology, use of VADs in the clinical setting, and pediatric cardiac transplantation to design a prototype, miniaturized VAD suitable for implantation in pediatric aged patients. The aims of this proposed Phase I SBIR program are to demonstrate via in vitro performance testing and in vivo implants the feasibility of this innovative design for pediatric, bridge-to-transplant circulatory support. If ultimately successful, this pump would have commercial application as a product marketed to hospitals in the United States and abroad. PROPOSED COMMERCIAL APPLICATION: The ultimate result of this research has commercial application as a product marketed to hospitals in the U.S. and abroad. Approximately 10% - 20% of patients alive with congenital heart defects may undergo cardiac transplantation.