EFFECT OF RACE ON BONE DENSITY IN CHILDREN

我们目前对骨质疏松症发病机制的理解是 受缺乏关于决定因素的信息的限制 在生长过程中获得的骨量。自从实现了 骨骼成熟时较大的骨量可能会降低患糖尿病的风险 晚年患上骨质疏松症，更好地了解 儿童和儿童生长发育过程中骨密度的决定因素 青春期是必需的。初步横断面研究 表明骨骼密度在青春期急剧增加 在男孩和女孩中，这种上升的程度在 黑人的青春期晚于白人。然而， 导致骨密度增加的因素 青春期与青春期发育的机制 在生命的这个时期，骨量的种族差异仍然存在 不确定。具体地说，血清变化的作用 几种重要的骨细胞代谢调节剂的水平 青春期，比如性类固醇和钙调节 荷尔蒙是未知的；有可能 骨骼在组织水平对这些重要调节因子的反应 对骨代谢的影响还有待进一步研究。 当前提案的目的是更仔细地审查 性激素和钙调节激素在体内的作用 青春期正常骨密度增加的决定因素 成长中的黑人和白人儿童。以下是目标 已划定： 1.研究大鼠椎体骨密度的变化。 性生活各阶段的松质骨和皮质骨密度 黑人和白人男性和女性的发育。 2.确定骨密度增加之间的关系 青春期与血清性类固醇和钙水平的关系 调节荷尔蒙。 3.为了确定青春期前对脊椎骨的测量 密度预测骨骼成熟时的骨密度。 4.比较骨骼的反应和生长的变化 雌激素对黑人和白人儿童激素分泌的影响 行政管理。

Our current understanding about the pathogenesis of osteoporosis is limited by a lack of information about the factors that determine the amount of bone gained during growth. Since the attainment of greater bone mass at skeletal maturity may reduce the risk of developing osteoporosis later in life, a better understanding of the determinants of bone density during growth in childhood and adolescence is required. Preliminary cross-sectional studies indicate that bone density increases dramatically during puberty both in boys and in girls and that the extent of this rise during late puberty is greater in blacks than in whites. However, the factors responsible for increases in bone density during adolescence and the mechanisms which account for the development of racial differences in bone mass at this time in life remain uncertain. Specifically, the role of alterations in the serum levels of several important modifiers of bone cell metabolism during puberty, such as sex steroids and calcium-regulating hormones is unknown; the possibility that variations in the response of bone at the tissue level to these important regulators of bone metabolism also wan-ants further investigation. It is the purpose of the current proposal to examine more closely the roles of sex steroids and calcium regulating hormones as determinants of the normal pubertal increase in bone density in growing black and white children. The following objectives are delineated: 1. To characterize the changes in vertebral bone density of cancellous and cortical bone density at each stage of sexual development in black and white males and females. 2 .To determine the relationship between increases in bone density during-puberty and the serum levels of sex steroids and calcium regulating hormones. 3 . To determine whether prepubertal measurements of vertebral bone density predict bone density at skeletal maturity. 4. To compare both the response of bone and the change in growth hormone secretion in black and white children after estrogen administration.