IMPROVED ULTRAFILTERS FOR BIOPROCESSING

本研究的目的和意义是发展经济 用于交叉流微滤和超滤的合理系统， 或消除浓度和凝胶极化对渗透物的影响 从而提高效率。 实现这一目标所需的目标是： L.评估和比较脉冲的相对优缺点 在各种横流通道配置中的流动和反向脉冲流动 以便提供有效的设计缩放数据。 2.进行仔细、详细的经济分析， 业绩效益与预期增减的比较 选定应用的建设和维护成本。 3.根据第一次和第二次会议产生的数据和决定， 目标，设计和建立一个示范系统， 评价 这项评估将在弗吉尼亚中心进行， 位于弗吉尼亚理工大学和州立大学校园内的生物技术 大学和一个或两个当地的生物技术公司， 将为第二阶段的工作提供建议和合作。

The aim and purpose of this research is the development of economically justifiable systems for crossflow micro- and ultrafiltration that reduce or eliminate the effects of concentration and gel polarization on permeate flux thereby increasing the efficiency. The objects required to achieve this aim are: l. Evaluate and compare the relative benefits and disadvantages of pulsed flow and reversing pulsed flow in various crossflow channel configurations in order to provide effective design scaling data. 2. Perform a careful, detailed economic analysis that will compare the performance benefits versus anticipated increases or decreases) in construction and maintenance costs for selected applications. 3. Based on data and decisions resulting from the first and second objectives, design and build a demonstration system for independent evaluation. This evaluation will be conducted at the Virginia Center for Biotechnology located on the campus of Virginia Polytechnic and State University and one or both of the two local biotechnology companies that will be advising and collaborating on this Phase II effort.