Dosimetry for molecular radiotherapy treatment planning (Stage 1 - no 23440)

分子放射治疗（MRT）是癌症的一种治疗方式。它涉及放射性原子的管理，目的是局部照射肿瘤。剂量学涉及测量每个疾病部位吸收的辐射剂量。目前，MRT中的许多治疗方法都是经验性的，或者具有固定剂量的放射性，没有足够的剂量测定。这可能导致不理想的治疗计划和患者过度暴露于辐射。该项目的目标是开发一个用于器官水平剂量测定的原型软件包，目的是通过优化和个性化给药剂量来提高治疗效果。以剂量学为主导的MRT治疗有望产生更好的结果——改善肿瘤控制、延长生存期、减轻症状和降低毒性。此外，可能对治疗反应不太好的患者可以提前识别，使他们免受不必要的治疗和潜在的并发症，并减少这些相对昂贵的治疗对医疗保健系统的财务影响。我们的最终目标是促进分子放射治疗剂量测定的更广泛实施，以帮助改善NHS内的癌症治疗结果。”

"Molecular radiotherapy (MRT) is a treatment modality for cancer. It involves the administration of radioactive atoms with the aim of locally irradiating tumours. Dosimetry is concerned with the measurement of the absorbed radiation dose to each disease site. Many of the treatments in MRT are currently prescribed empirically or with a fixed quantity of radioactivity, without adequate dosimetry. This can lead to suboptimal treatment planning and patient over-exposure to radiation.The goal of this project is to develop a prototype software package for organ-level dosimetry, with the aim of improving treatment efficacy by optimization and personalisation of the administered dose. MRT treatments that are dosimetry-led are expected to produce improved outcomes - improved tumour control, longer survival, reduced symptoms and lower toxicities. Furthermore, patients who are unlikely to respond well to the treatment could be identified in advance, sparing them from unnecessary treatment and potential complications, as well as reducing the financial impact of these relatively high-cost treatments on the healthcare system. Our ultimate aim is to facilitate the wider implementation of dosimetry for molecular radiotherapy as to help improve cancer outcomes within the NHS."