INEXPENSIVE HIGH RESOLUTION PET DETECTOR DEVELOPMENT

该项目的长期目标是改善成像， 正电子相机（PET）的经济性能，使其能力 来成像器官功能和化学可以得到更广泛的应用。的 PET的探测系统决定了其图像质量和成本。这 该提案旨在为PET开发一种新的探测器设计概念， 服务于这些目标。该项目将（a）评估潜力， 不可预见的困难研究基本特性：闪烁 分布和控制它的新技术，光学 特性，晶体间康普顿相互作用串扰，以及 符合定时分辨率，（B）开发使用新的 光控制技术，以实现最终的空间分辨率 可能的和测试原型的性能特征，和 (c)开发一种新的计数率增强电路，并将其集成到 用于防止/校正检测信号堆积的原型检测系统 从而提高了计数率能力 建议的探测器。该算法/电路也应该是可用的 在标准伽马和PET照相机中， 特别是高剂量0 - 15、Rb-82和单克隆抗体显像。两 将研究检测器概念的实现：（1）高 分辨率低成本的实现，这可能会降低 PET价格从240万美元降至140万美元，同时保持高分辨率， 使用与大多数当前商业PET相同尺寸的探测器（6.5 × 6.5mm）， (2)一个非常高的分辨率实现， 通过将探测器尺寸从6.5x6.5mm减小到 2.6x2.6mm，从而将探测器数量增加了六倍，同时 这可能会使PET的价格降低25%。

The long term objectives of this project are to improve the imaging and economic performance of positron cameras (PET) so that their capability to image organ function and chemistry can be more widely applied. The detection system of a PET dictates its image quality and cost. This proposal aims at developing a new detector design concept for PET to serve these objectives. This project will (a) evaluate potential and unforeseen difficulties study basic characteristics: scintillation distribution and new techniques for controlling it, optical characteristics, inter-crystal Compton interaction cross-talk, and coincidence timing resolution, (b) develop prototype detectors using new light controlling techniques to achieve the ultimate spatial resolution possible and test the performance characteristics of the prototypes, and (c) develop a new count-rate enhancing circuit and integrate it into the prototype detection system to prevent/correct for detection signal pileup in high count-rate situations thus enhancing the count-rate capability of the proposed detector. This algorithm/circuit should also be usable in standard gamma and PET cameras to enhance their count rate capability, especially for high dose 0-15, Rb-82 and monoclonal antibody imaging. Two implementations of the detector concept will be investigated: (1) a high resolution. low cost implementation which may potentially decrease the $2,400,000 PET price to $1,400,000 while maintaining high resolution by using the same size detectors (6.5x6.5mm) as most current commercial PET, (2) a very high resolution implementation which significantly improves image resolution by decreasing the detector size from 6.5x6.5mm to 2.6x2.6mm, thus increasing the number of detectors by six times while potentially lowering the price of PET by 25%.