ANTIBODY INTERVENTION IN COCAINE ADDICTION

目前还没有可靠的药物治疗可卡因 成瘾 另一种方法是阻止可卡因进入 中枢神经系统产生抗可卡因抗体。的 本研究的目的是确定一种活性 预防可卡因成瘾复发免疫方法。可卡因 或可卡因衍生物将用于半抗原化确定的载体。 这些 缀合物将用于免疫小鼠。 如果高滴度可卡因特异性 可以产生阻断可卡因毒性作用的抗体 它表明通过免疫引起的抗体可以阻断CNS 介导可卡因的增强特性。 定义的能力 结合免疫以改变动物模型中的自我成瘾， 在第二阶段研究。 如果在动物模型中证明了有效性， 用确定的缀合物进行的免疫接种可以与 目前的药物滥用治疗计划，其能力，以防止 可卡因成瘾的人在3-4年内复发。

Currently there are no reliable pharmacologic treatments for cocaine addiction. An alternate approach is to block access of cocaine to the central nervous system by the generation of anti-cocaine antibody. The goal of this research is to determine the feasibility of an active immunization approach to prevent relapse in cocaine addiction. Cocaine or cocaine derivatives will be used to haptenate defined carriers. These conjugates will be used to immunize mice. If high titer cocaine-specific antibody can be generated which blocks toxic effects upon cocaine challenge it suggests antibody elicited via immunization can block CNS mediated re-inforcing properties of cocaine. The ability of defined conjugate immunization to alter self-addiction in animal models will be studied in Phase II. Provided efficacy in animal models is demonstrated, immunization with defined conjugates can be tested in concert with current substance abuse treatment programs for its ability to prevent relapse in cocaine addiction in humans within 3-4 years.