DIAGNOSTIC CENTERS FOR PSYCHIATRIC LINKAGE STUDIES

这个项目来自约翰·霍普金斯大学精神病学系 为了响应NIMH的申请请求，寻求开发一种 双相情感障碍连锁研究诊断中心。这个 该项目将是合作协议计划的一部分，该计划涉及Active NIMH工作人员和其他诊断中心的合作。该项目 将致力于在合作的背景下制定适当的 计划使用具有高度信息量的家庭结构的小家庭 对于连锁研究，寻找并招募66个这样的双相情感障碍家庭到 研究、开发和实施我们的临床诊断方案以分类 双极型家族中受影响和未受影响的表型，以及 采集血液样本并运往中心设施进行淋巴细胞检测 转化成永久细胞系，用于DNA连锁研究。

This project from the Johns Hopkins University Department of Psychiatry in response to an NIMH Request for Applications seeks to develop a Diagnostic Center for Linkage Studies of Bipolar Affective Disorder. The project will be part of a cooperative agreement program involving active collaboration of NIMH staff and other diagnostic centers. The project will aim to develop, in the context of the collaboration, an appropriate plan for use of small families with highly informative family structures for linkage studies, to find and recruit 66 such bipolar families to the study, to develop and carry our clinical diagnostic protocol to classify the affected and unaffected phenotypes in the bipolar families, and to collect and ship to a central facility blood samples for lymphocyte transformation into permanent cell lines for DNA based linkage studies.