DIAGNOSTIC CENTERS FOR PSYCHIATRIC LINKAGE STUDIES

这个来自约翰霍普金斯大学精神病学系的项目 为了响应NIMH的申请要求， 双相情感障碍连锁研究诊断中心。的 该项目将是一个合作协议计划的一部分， NIMH工作人员和其他诊断中心的合作。项目 在合作的背景下，将致力于制定一个适当的 计划使用具有高度信息化家庭结构的小家庭 为了进行联系研究，寻找并招募66个这样的双相情感障碍家庭加入 研究，制定和执行我们的临床诊断方案，以分类 双相家族中受影响和未受影响的表型，以及 收集血液样本并运送到中心设施用于淋巴细胞 转化成永久细胞系用于基于DNA的连锁研究。

This project from the Johns Hopkins University Department of Psychiatry in response to an NIMH Request for Applications seeks to develop a Diagnostic Center for Linkage Studies of Bipolar Affective Disorder. The project will be part of a cooperative agreement program involving active collaboration of NIMH staff and other diagnostic centers. The project will aim to develop, in the context of the collaboration, an appropriate plan for use of small families with highly informative family structures for linkage studies, to find and recruit 66 such bipolar families to the study, to develop and carry our clinical diagnostic protocol to classify the affected and unaffected phenotypes in the bipolar families, and to collect and ship to a central facility blood samples for lymphocyte transformation into permanent cell lines for DNA based linkage studies.