DEFICITS IN AWARENESS OF ILLNESS IN SCHIZOPHRENIA

许多报告表明，大多数精神分裂症患者都有 自知力差或缺乏疾病意识(LAI)。具体地说，这样 患者否认、不承认或更广泛地说，缺乏对 有精神错乱或精神错乱症状的。这一点很重要 由于无法获得，该主题在很大程度上被忽略了 心理测量学上合理的评估方法。我们认为洞察力是一种 多维结构，并开发了评级标尺， LAI在各种表现形式中的离散和全局方面 生病了。拟议的项目将：1)完成对 几种叶面积指数测定方法的信度和效度；2)进一步 调查量表的心理测量学特性，以评估无意识 精神障碍(SUMD)；3扩展先前检查预后的工作 叶面积指数亚型的价值；4)检验特定假说 关于精神分裂症患者LAI的神经心理相关性。 这项研究将在纽约州精神病院进行。 纽约精神分裂症研究所(NYSPI)的精神分裂症研究小组 NYSPI和哥伦比亚大学精神分裂症研究合作中心 大学。先前的研究表明，LAI可能有显著的 对精神分裂症长期病程的预测力 可能会影响治疗方面，如服药依从性。致我们的 知识方面，目前还没有关于赖的神经心理学的研究。 考察赖的现象学，建立一个心理测量学的健全 量化方法，并进行神经心理学检查 相关因素对促进我们的理解具有相当重要的意义。 精神分裂症和它的治疗。

Many reports indicate that a majority of patients with schizophrenia have poor insight or lack awareness of illness (LAI). Specifically, such patients deny, fail to acknowledge, or more broadly, lack awareness of having a mental disorder or symptoms of a mental disorder. This important topic has been largely neglected due to the unavailability of psychometrically sound assessment methods. We propose that insight is a multidimensional construct and have developed rating scales that sample discrete and global aspects of LAI across a variety of manifestations of illness. The proposed project will: 1) complete a comparative study of the reliability and validity of several methods of measuring LAI; 2) further investigate the psychometric properties of the Scale to assess Unawareness of Mental Disorder (SUMD); 3 extend previous work examining the prognostic value of subtyping by degree of LAI; and 4) test specific hypotheses regarding the neuropsychological correlates of LAI in schizophrenia. The present study will be conducted at New York State Psychiatric Institute's (NYSPI) Schizophrenia Research Unit, which serves as a collaborative center for schizophrenia research at NYSPI and Columbia University. Previous work has suggested that LAI may have significant predictive power with respect to the long-term course of schizophrenia and may impact on treatment dimensions such as medication compliance. To our knowledge, there have been no studies of the neuropsychology of LAI. Examining the phenomenology of LAI, establishing a psychometrically sound method for its quantification, and examining the neuropsychological correlates are of considerable significance in advancing our understanding of schizophrenia and its treatment.