Engineering an environmentally-friendly metered dose inhaler

该项目旨在提供一个新的模拟框架，以准确地预测计量吸入器喷雾的行为，使用由研究人员开发的快速蒸发湍流的先进数值方法。该项目希望通过首次将非稳定非平衡热力学、湍流和喷雾模型结合起来，产生有关这些设备中复杂物理的新知识。该项目的预期成果包括预测和优化吸入器性能的新能力，以适应环保的替代推进剂。这将大大有利于制药行业，因为它将加速下一代吸入器和推进剂的设计。

This project aims to deliver a novel simulation framework to accurately predict the behaviour of metered dose inhaler sprays using advanced numerical methods for flash-evaporating turbulent flows developed by the investigators. The project expects to generate new knowledge of the complex physics which occur in these devices through a first of its kind combination of unsteady non-equilibrium thermodynamics, turbulence and spray models. Expected outcomes of this project include a novel ability to predict and optimise the performance of inhalers to suit environmentally-friendly replacement propellants. This will significantly benefit the pharmaceutical sector as it will accelerate the design of next-generation inhalers and propellants.