Method for manufacture of biodegradable microsphere as matrices for control and stabilisation of aluminium containing vaccine adjuvants

在这项提案中，Q Chip正在寻求解决疫苗生产和分销的一个主要障碍。虽然疫苗接种计划对全球健康有很大好处，但据估计，高达50%的疫苗库存由于储存条件的失误而被浪费；铝佐剂晶体(许多疫苗的基本成分)稳定性有限，需要特定的冷藏系统以防止产品损坏。我们提出了一种新的创新系统，通过使用新的、完全生物兼容的微球载体来稳定这些关键的疫苗成分。我们希望研究铝佐剂晶体在一种独特的基于微球的技术提供的超多孔基质中的形成。开发这样的系统可以使我们能够生产稳定和增强的疫苗产品，降低疫苗分发的成本，并在具有全球影响的治疗领域引领发展。

In this proposal, Q Chip is seeking to address a major obstacle for the production & distribution of vaccines. Whilst vaccination programmes have substantial benefits for global health, it is estimated that up to 50% of vaccine stocks are wasted due to lapses in storage conditions; aluminium adjuvant crystals (an essential component of many vaccines) have limited stability & require specific cold storage systems to prevent product damage. We propose a new, innovative system for stabilising these key vaccine components, by using novel, completely biocompatible microsphere supports. We wish to investigate the formation of aluminium adjuvant crystals within a hyperporous matrix provided by a unique microsphere-based technology. Developing such a system could allow us to produce stabilised & enhanced vaccine products, reducing the cost of vaccine distribution & leading the development in a therapeutic area with a global impact.