RESEARCH METHODS FOR PRE-PROFESSIONAL STUDENTS

MBRS计划为教职员工和学生提供了独特的机会 在生物医学-健康科学领域进行高质量的研究 在这么小的本科生里几乎是不可能的 少数群体机构。拟开展的工作分为五个项目 每年将有11名学生参与，并将利用专业知识 由五名教职员工和顾问组成。 巴拉博士将研究常见家蚊的系统学 用新开发的DNA为基础的致倦库蚊 技术，并与常规生化技术进行比较 酶电泳法。 乔普拉博士将研究4-喹诺酮类药物的比较疗效 来自不同临床分离株和相似病原菌的头孢菌素 从体外不同部位分离得到。 希克斯女士将研究、记录和评估 虚弱老年人的心理控制源与他们的 参与他们的医疗保健决策。 拉塞尔博士将利用各种合成方法来制备吲哚- 融合4-喹诺酮类潜在抗菌剂及其制备 NCI研究人员建议的褪黑素类似物。前者将是 在项目2的主持下进行测试，后者由NCI筛选 作为细胞有丝分裂抑制剂。 塔博尔博士将合成一系列阳离子苯并噻唑染料 在染料中含有一个、两个或三个乙炔基团 生色团。染料和染料中间体，含有官能化 还将合成侧链羧酸基团或衍生物。 将进行紫外可见、红外、质子和碳核磁共振研究 为了表征光谱性质并建立 这些化合物的立体化学。精选的化合物将在 利用体外和体内肿瘤模型进行肿瘤治疗。

The MBRS Program provides unique opportunity to faculty and students to conduct quality research in biomedical-health sciences which would have been practically impossible at such a small undergraduate predominately minority institution. The proposed work is divided into five projects which will involve eleven students yearly and will utilize the expertise of five faculty members and consultants. Dr. Bhalla will investigate the systematics of the common house mosquito Culex pipiens quinquefasciatics using the newly developed DNA-based technology and compare with conventional biochemical techniques based on enzyme electrophoresis. Dr. Chopra will investigate the comparative effectiveness of 4-quinolones from cephalosporins on different clinical isolates and similar pathogen isolated from different body sites in-vitro. Ms. Hicks will study, document, and evaluate the extent to which there is a correlation between locus of control for the frail elderly and their involvement in decision making for their health care. Dr. Russell will utilize various synthetic methods to prepare indole- fused 4-quinolones as potential antimicrobial agents and to prepare Melatonin analogs suggested by NCI researchers. The former will be tested within the auspices of Project 2 and the latter screened by NCI as cell mitosis inhibitors. Dr. Tabor will synthesize a series of cationic benzothiazole dyes containing one, two, or three acetylene groups within the dye chromophore. Dyes and dye intermediates, containing a functionalized pendant carboxylic acid group or derivative, will also be synthesized. UV-visible, infrared, and proton and carbon NMR studies will be conducted to characterize the spectral properties and to establish the stereochemistry of these compounds. Select compounds will be studied in cancer therapy using in vitro and in vivo tumor models.