EGF EFFECTS ON RAT ORTHODONTIC TOOTH MOVEMENT AND MOLAR DRIFT

表皮生长因子对大鼠正畸牙齿移动和磨牙移动的影响 许多生物学效应都归因于EGF，包括 对长骨重塑的影响。表皮生长因子的主要来源是 大鼠是颌下腺。涎腺切除术(SX)已被证明 消耗唾液和血清中的EGF水平。这项研究是在 确定EGF对牙槽骨的影响，作为证据； 正畸牙齿移动反映了细胞的募集和 建立微生态环境，使适当的 组织和重塑。恢复运动的最后阶段 表示组织周转，它允许减少 施加的菌株。大鼠的OTM也必须与自然的 磨牙向远中漂移的趋势约为7 微米/天。口服或不口服SX的疗效观察 皮下注射EGF对男性OTM和MD的影响 老鼠。成年大鼠(400-425g)分为以下几组 组(n=5个/组)：1)Sx，力(40g初始倾斜力 上颌磨牙)；2)SX，不用力；3)SX，不用力，EGF；4)假手术(Sh)； 5)Sh，力，EGF；6)Sh，无力；7)Sh，无力，EGF。OTM和MD 对于腭部植入物，使用口外 SX大鼠修复磨牙矫治时的头影测量 漂移，改变了方向，提高了速度。同样， 即使考虑到近侧漂移，接受EGF治疗的Sh动物也显示 OTM第二阶段的显著刺激，表现为两个- 牙齿移动量比单独在Sh中看到的增加一倍。它 似乎EGF可能参与了OTM的第二阶段和 正常上颌磨牙偏移。 关键词：骨科，大鼠，表皮生长因子，唾液腺

EGF Effects on Rat Orthodontic Tooth Movement and Molar Drift Many biological effects have been attributed to EGF, including effects on long bone remodeling. The major source of EGF in the rat is the submandibular gland. Sialodenectomy (Sx) has been shown to deplete both salivary and serum EGF levels. This study was done to determine the effects of EGF on alveolar bone as evidence by; orthodontic tooth movement reflects recruitment of cells and the establishment of microenivronment that will allow the appropriate tissue and remodeling. The final phase of resumed movement represents tissue turnover which allows the reduction of the applied strain. OTM in rats must also contend with the natural tendency of molars to drift distally at the rate of ca. 7 micrometer/day. The effects of Sx with or without orally administrated EGF on OTM and Md was studies in male Sprague-Dawley rats. Adult rats(400-425g) were divided into the following groups(n=5/group): 1)Sx, force(40g initial tipping force to maxillary molars); 2)Sx, no force; 3)Sx, no force, EGF; 4)Sham(Sh); 5)Sh, force, EGF; 6)Sh, no force; 7)Sh, no force, EGF. OTM and MD were determined, with respect to palatal implants, using extraoral cephalometries obtained at appliance to Sx rats restored molar drift, changed its direction and enhanced its rate. Similarly, even accounting for mesial drift, Sh animals receiving EGF showed a marked stimulation of the second phase of OTM, exhibiting a two- fold increase in tooth movement over that seen in Sh alone. It appears that EGF may be involved in the second phase of OTM and in normal maxillary molar drift. Key Words: Othrodontics, Rats, EGF, Salivary Glands