Quiescent Microbial Cell Factories

许多用于制造塑料、燃料和商品的化学品都是从发酵罐中各种原料上生长的微生物中生产出来的。这个项目将推动创新技术的进步，这种技术可以暂停不必要的细胞新陈代谢和生长，同时仍能促进化学产品的生产，这种状态被称为静止。静止单元技术(Q-Cells)的优势使生物反应器在最佳生产条件下运行，同时提高了生产率，有效和经济地利用了原料，并减少了废物的产生。改善静息控制的机理将在工业发酵条件的限制下进行规模缩小的研究。这项研究将评估该技术在提高工业生物技术生产大宗化学品竞争力方面的普遍适用性。

Many of the chemicals used to manufacture plastics, fuels and commodities are produced frommicroorganisms grown on various feedstocks in fermenters. This project will progress innovativepatented technology which suspends unnecessary cell metabolism and growth while still enablingenhanced production of chemical products, a state known as quiescence. The advantages of quiescentcell technology (Q-Cells) are enabled for bioreactors operating under optimal production conditionswith concomitant improved productivity, efficient and cost effective use of the feedstock and reducedwaste generation. The mechanism to improve control of quiescence will be investigated within theconstraints of industrial fermentation conditions under scale-down. This study will assess the genericapplicability of the technology to improve competitiveness of Industial Biotechnology to produce bulkchemicals.