Active and passive Ingredient wet Milling (AIM)

这个项目评估了Concor湿法研磨技术在制药工业中应用于纳米材料的分散和解聚以及纳米乳剂生产的可行性。虽然主动和被动纳米材料在制药工业中的应用的重要性已经得到确认，但许多应用仍处于早期开发阶段。技术路线图表明，一个关键的工艺领域是在工业规模上高效和有效地分散纳米材料。纳米材料通常以粉末的形式出现，往往会形成初级颗粒的聚集体，这主要是由于范德华力的作用，这些力比初级颗粒大几个数量级。如果要利用纳米材料的影响，然后在目标产品中均匀分布，则需要将这些纳米材料分散回原始颗粒大小。纳米级乳剂是另一个越来越受关注的领域，因为许多递送系统包括液体形式的不溶原料药，例如麻醉剂乳剂，这些都可以从液滴尺寸的减小中受益。这需要类似的颗粒分散方法，因为颗粒间作用力的问题对两者都很常见。虽然超声波和介质研磨在较小的规模上使用，高压均质机和高剪切混合器在较大的规模上使用，但这些技术的使用有明显的缺点。作为一种替代方案，Concor技术已经被证明在一系列纳米材料上提供了许多好处。这个项目旨在通过设计和建造一个小型卫生系统并在多达3个材料系统上进行测试，来测试在制药行业内应用Concor技术来满足这一需求的可行性。除了在项目期间取得的结果外，项目结束时将提供Concor系统以供进一步测试和演示。

"This project evaluates the feasibility of applying ConCor wet milling technology to the dispersion and deagglomeration of nanomaterials and the production of nano emulsions within the Pharmaceutical Industry.Whilst the importance of the application of active and passive nanomaterials within the Pharmaceutical industry has been identified, many applications are still at an early stage of development.Technology road-mapping indicates that one key process area is the efficient and effective dispersion of nanomaterials at industrial scales. Often presented as powders, nanomaterials tend to form agglomerates of primary particles, mainly due to van der Waals' forces, that are orders of magnitude larger than the primary particles. These need to be dispersed back down to primary particle sizes if the effects of the nanomaterials are to be exploited and then evenly distributed within the target product. Nano scale emulsions are another area of increasing interest, as many delivery systems include insoluble APIs in liquid form, e.g. anaesthetic emulsions, and these can benefit from droplet size reduction. This requires similar approaches to particle dispersions as the problem of inter particulate forces are common to both.Whilst sonication and media milling have been used at smaller scales, and high pressure homogenisers and high shear mixers at larger scales, there are clear drawbacks to the use of these technologies.As an alternative, ConCor technology has been demonstrated to provide a number of benefits over a range of nanomaterials. This project aims to test the feasibility of applying ConCor technology to meet this need within the Pharmaceutical Industry by designing and building a small-scale hygienic system and testing it on up to 3 material systems.In addition to the results obtained during the project, the resultant ConCor system will be made available for further testing and demonstrations at the end of the project."