ESTROGEN AND OXIDATIVE STRESS IN POSTMENOPAUSAL WOMEN

氧化应激指的是自由基氧化增加和 抗氧化剂防御。绝经后妇女患糖尿病的风险增加 冠心病，并可能因以下原因而容易产生氧化应激 雌激素水平下降。雌激素与氧化的关系 压力将通过一项为期两年的纵向跟踪研究进行调查。 40例绝经后妇女接受雌激素替代治疗一年的比较 有40名年龄匹配的绝经后妇女没有接受雌激素替代治疗。 测量的变量将包括：脂蛋白氧化产物 (共轭双烯)抗氧化剂、促氧化剂、饮食和物理 活动。描述性统计、协方差多元分析和 在数据分析中将使用相关统计。

Oxidative Stress refers to increased free-radical oxidation and a loss of antioxidant defenses. Postmenopausal women have an increased risk for coronary heart disease and may be prone to oxidative stress as a result of declining estrogen levels. The relationship between estrogen and oxidative stress will be investigated by a 2-year, longitudinal, follow-up study comparing 40 postmenopausal women taking estrogen replacement for one-year with 40 age-matched, postmenopausal women not on estrogen replacement. Measured variables will include: lipoprotein oxidation products (conjugated dienes) antioxidants, pro-oxidants, diet, and physical activity. Descriptive statistics, multivariant analyses of covariance, and correlational statistics will be used in the data analysis.