AUTOMATED PAP TEST SCREENING FOR QUALITY CONTROL

在这项研究中，主要目标是开发一种自动宫颈癌， 子宫颈薄层人工筛检后涂片分析系统 样品作为质量控制（QC）工具。 该设备将测量 核特征被称为“核相关变化”（MAC），以识别 通过人工方法假阴性的样本中的疾病。 在 在当前的技术水平和监管环境下， 该系统的开发将在实验室中发挥重要作用 质量，并可能在自动化初级产品之前很久就进入市场 筛选装置 MAC的使用是新的和创新的，因为它允许 以非常合理的系统成本进行快速和准确的处理。 同相 二、将开发和测试一个完全自动化的原型。 具体 研究领域是1）染色剂的优化，2） 多个焦平面，3）分类器的优化，以及4）完成 和测试一个完全自动化的原型。 规格和设计 商业文书的审查将在第二阶段结束时开始， 进入第三阶段。 拟议的商业应用：该器械将提供增强的 所有细胞学实验室的巴氏试验分析质量控制 国际吧 目前的做法是重新筛选10%的阴性涂片， 不够。 实施快速和廉价的自动化系统 在人工筛选后使用将导致准确性增加， 改善医疗保健。

In this research, the primary goal is to develop an automated cervical smear analysis system for use after manual screening of thinlayer cervical specimens as a quality control (QC) instrument. The device will measure nuclear features termed "Malignancy Associated Changes" (MACs) to identify disease in samples that are falsely negative by manual methods. At the current levels of technology and in the present regulatory environment, the development of such a system will play an important role in laboratory quality, and will likely reach the market long before an automated primary screening device. The use of MACs is new and innovative in that it allows fast and accurate processing at a very reasonable system cost. In Phase II a fully automated prototype would be developed and tested. Specific research areas are 1) the optimization of the stain, 2) the use of multiple focal planes, 3) optimization of classifiers, and 4) completion and testing of a completely automated prototype. Specification and design of a commercial instrument will begin at the end of Phase II and continue into Phase III. PROPOSED COMMERCIAL APPLICATION: This device would provide enhanced quality control for Pap test analysis in all cytology laboratories worldwide. The current practice of rescreening 10% of negative smears is not adequate. Implementation of a fast and inexpensive automated system used after manual screening would result in increased accuracy and improved healthcare.