AUTOMATED PAP TEST SCREENING FOR QUALITY CONTROL

在这项研究中，主要目标是探索一种 人工筛查后使用的自动宫颈分析系统 薄层宫颈标本作为质控(QC)工具。我们 会检验这样一种假设，即核特征被称为“恶性肿瘤” 仪器测量的关联变化(MACs)可用于 在人工方法发现假阴性的样本中识别疾病。 在目前的技术水平和目前的监管下 环境，这样一个系统的发展将起到重要的作用 在实验室质量方面，很可能在进入市场之前很久 自动初级筛查设备。第一阶段的基本目标 可行性研究的目的是利用 基本细胞的制备、光电子学和特性 扫描仪。此应用程序的新方面和创新方面 包括Mac在大范围筛选环境中的应用 (之前对Mac的工作涉及手动选择细胞，手动 重点，而且仅限于有限的测试)，此外，使用这种 仪器是一种低成本的质量控制技术，而不是主要的筛选器。在……里面 第二阶段将开发和测试全自动原型， 包括用户界面。

In this study, the primary goal is to explore the development of an automated cervical analysis system for use after manual screening of thinlayer cervical specimens as a quality control (QC) instrument. We shall test the hypothesis that nuclear features termed "Malignancy Associated Changes" (MACs) measured by the instrument can be employed to identify disease in samples found to be false negative by manual methods. At the current levels of technology and in the present regulatory environment, the development of such a system will play an important role in laboratory quality, and will likely reach the market long before an automated primary screening device. The basic goal of the Phase I feasibility study is to establish the presence of MACs using the preparation, optoelectronics, and features available on a basic Cytyc scanning instrument. New and innovative aspects of this application include the application of MACs in a wide scale screening environment (previous work with MACs has involved manual selection of cells, manual focus, and only limited testing) and, in addition, the use of such an instrument as a low cost QC technique rather than a primary screener. In Phase II a fully automated prototype would be developed and tested, including a user interface.