JERUSALEM INFANT DEVELOPMENT STUDY: ADOLESCENT FOLLOW-UP

这项拟议的研究将考察广泛的行为变量 在一群以色列青少年中，精神分裂症的高危人群。四十 父母患有精神分裂症的孩子将与50人组成的小组进行比较 父母有其他精神障碍的儿童和40名有精神障碍的儿童 精神健康的父母。提议的样本中约有一半是 在他们母亲怀孕期间招募，并被跟踪 作为耶路撒冷婴儿发育的一部分，从婴儿期开始纵向 学习。剩下的一半是在学校招募和第一次评估的- 年龄。青少年随访工具将包括以下措施 信息处理与注意功能、神经运动 功能、临床状况和家庭环境。 拟议研究的目标是澄清不断增长的文献 这表明精神分裂症患者的子女有神经行为症状 这可能是后来精神分裂症崩溃的易感性的标志。 拟议的研究将试图以更具体的方式确定 比以往的工作更能确定这类神经行为体征的性质 它们是否可以在不同阶段连续观察到 生命周期，并确定他们如何结合家庭因素， 与精神分裂症的发病前症状有关 青少年。

The proposed research will examine a broad range of behavioral variables in a group of Israeli adolescents at high risk for schizophrenia. Forty children with schizophrenic parents will be compared to a group of fifty children whose parents have other mental disorders and forty children with mentally healthy parents. Approximately half of the proposed sample was recruited during their mothers' pregnancies and have been followed longitudinally since infancy as part of the Jerusalem Infant Development Study. The remaining half was recruited and first assessed during school- age. Adolescent follow-up instruments will include measures of information processing and attentional functioning, neuromotor functioning, clinical status, and family environment. The goal of the proposed research is to clarify the growing literature suggesting that children of schizophrenics have neurobehavioral signs which may be markers of vulnerability to later schizophrenic breakdown. The proposed research will attempt to identify with greater specificity than previous work the nature of such neurobehavioral signs, to determine whether they can be observed with continuity during various stages of the life cycle, and to determine how they, in combination with family factors, are related to premorbid symptoms of schizophrenia observed during adolescents.