PROGNOSTIC SIGNIFICANCE OF AXIS I/AXIS II COMORBIDITY

人格障碍（PD，DSM III-R轴II障碍）是重要的 导致功能严重受损并需要 广泛的治疗。 在许多情况下，它们沿着一种或多种 轴I精神病诊断为共病。 在这种情况下， 预后不良者较多。 由于PD被假定为代表相对稳定的特征， 通常在青春期就能发现， 科摩罗对青年人的结果特别感兴趣。 拟议 这项研究将测试由四种不同的假设产生的一系列假设。 理解人格障碍的理论方法： 发展，体质气质，人际关系，和 光谱/遗传方法。 这些假设的检验将使用轴I和轴II上的数据 精神病诊断收集了三次在十年期间， 约800名晚期青少年和年轻人通过结构化诊断 对年轻人和他们的母亲的采访。 这个独特的数据集在一个 随机抽样的青少年包括在4岁时评估有关措施 从孩子们1岁到10岁的时间点开始。 气质、发展角色功能和人际关系的测量 这些评估中的问题将被用来确定 它们解释了Axis的发生和预后影响， I -科摩罗第二轴。 精神疾病家族史 通过母亲访谈收集的信息将增加有关家庭方面的信息 这些疾病。 这项调查将增加我们的知识， 理解第一轴的过程和决定因素 二关系。 特别是，它将提供第一个系统的 关于人格障碍对持续性的影响的证据 轴I诊断从青春期到年轻的成年人在一个 流行病学样本采集用于治疗。

Personality disorders (PDs, DSM III-R Axis II disorders) are important problems leading to significant impairment of function and requiring extensive treatment. In many cases they occur along with one or more Axis I psychiatric diagnoses as comorbid conditions. In such cases a more negative prognosis is found. Because PDs are assumed to represent relatively stable characteristics that are usually first identifiable in adolescence, the impact of comorbidity on young adult outcome is of special interest. The proposed study will test a series of hypotheses generated by four different theoretical approaches to understanding personality disorders: developmental, constitutional-temperament, interpersonal, and spectrum/genetic approaches. Tests of these hypotheses will employ data on Axis I and Axis II psychiatric diagnoses collected at three times in a ten year period on about 800 late adolescents and young adults by structured diagnostic interviews of the youths and their mothers. this unique data set on a random sample of youth includes assessment of relevant measures at 4 points in time beginning when the children were age 1 through 10. Measures of temperament, developmental role function, and interpersonal problems in these assessments will be employed to determine the extent to which they account for the occurrence and prognostic impact of Axis I - Axis II comorbidity. Family history of psychiatric disorder collected by maternal interview will add information on familial aspects of these disorders. This investigation will add to our knowledge and understanding of the processes and determinants underlying Axis I - Axis II relationships. In particular, it will provide the first systematic evidence regarding the impact of personality disorder on the persistence of Axis I diagnoses from adolescence to young adulthood in an epidemiological sample unselected for treatment.