SCHIZOPHRENIA RELATED TRAITS

几种不正常的神经精神特征在 精神分裂症患者的非精神分裂症亲缘关系大于临床 精神分裂症。在这些潜在的表达中，突出的是“潜伏的 责任“是眼球运动障碍，思维障碍，以及 精神分裂症谱系障碍和特征。是否可以使用 精神分裂症基因的另一种更普遍的表现 将通过扩大链接研究的池来增加链接研究的力量 见多识广的家庭。为了给连锁研究提供最佳信息量， 然而，准确测量这些特征的方法需要 已建立的，包括关于它们的分布、特性、 稳定性和关联性。这些特征中的每一个都已经被研究过了 广泛存在于精神分裂症患者及其家属中。本研究 解决了这些特征在相同个体内的共同聚集 以及它们的个人和集体在区分105 105例正常对照和75例精神分裂症患者同胞的对照研究 来自75个控制组的兄弟姐妹。我们将使用判别分析， Logistic回归、多元方差分析和正态混合 比较精神分裂症患者与正常对照及其兄弟姐妹的模型 有正常兄弟姐妹的精神分裂症患者。这些数据是对来自 麦克莱恩精神分裂症合作项目(《合作生物学》 精神分裂症研究》；MH 31154)，它正在研究共同聚集 这些特征(和其他)在精神分裂症患者的家庭中，但在 不同的家庭设计。

Several abnormal neuropsychiatric traits are more prevalent among the nonschizophrenic biological relatives of schizophrenics than is clinical schizophrenia. Prominent among such potential expressions of "latent liability" are eye movement dysfunctions, thought disorder, and schizophrenia spectrum disorders and traits. The availability of alternative, more prevalent manifestations of the schizophrenia genotype would increase the power of linkage studies by broadening the pool of informative families. To be optimally informative for linkage studies, however, methods for accurately measuring these traits need to be established, including information about their distribution, specificity, stability, and interrelatedness. Each of these traits has been studied extensively in schizophrenics and their family members. This study addresses the co-aggregation within the same individuals of these traits and their individual and collective usefulness in discriminating 105 schizophrenics from 105 normal controls and 75 siblings of schizophrenics from 75 sibling of controls. We will use the discriminant analysis, logistic regression, multivariate analysis of variance, and normal mixture models to compare schizophrenics with normal controls and siblings of schizophrenics with siblings of normals. These data complement those from the McLean Schizophrenia Collaborative Project ("Collaborative Biological Research in Schizophrenia"; MH 31154), which is studying the co-aggregation of these traits (and others) within families of schizophrenics, but in a different family design.