CALCIUM AND INTEGRATION IN PYRAMIDAL CELLS

描述：这是一份经过修订的重新提交的竞争性续订 申请继续研究电的离子基础 海马锥体细胞树突树的旋光性 细胞内离子活性的探针。 最近的实验工作 显示突触激活过程中的大量Ca进入是通过 电压依赖性钙通道激活后，钠尖峰。这 一项提案将研究特定的突触输入和代理是否 影响钾离子通道影响钙离子进入的空间范围。 强烈的突触刺激可以引起树突状细胞的钙峰， 突触输入和K通道调节剂对突触传递的影响 将研究树突状Ca尖峰。 将努力 测量通过NMDA受体通道的Ca内流。电压类型- 将检查参与Ca内流的依赖性Ca通道。

DESCRIPTION: This is a revised re-submission of a competitive renewal application to continue studies on the ionic basis of electrical optical activity in dendritic trees of hippocampal pyramidal cells using probes of intracellular ionic activity. Recent experimental work shows that much Ca entry during synaptic activation is through voltage-dependent Ca channels activated subsequent to Na spiking.This proposal will examine whether specific synaptic inputs and agents affecting potassium channels affect the spatial extent of Ca entry. Strong synaptic stimulation can evoke dendritic Ca spikes, and the effects of synaptic inputs and K channel modulators on propagation of dendritic Ca spikes will be studied. An effort will be made to measure Ca entry through NMDA receptor channels. The types of voltage- dependent Ca channels involved in Ca influx will be examined.