Mechanisms of immune protection for infectious laryngotracheitis virus

本课题旨在探讨鸡传染性喉气管炎病毒的免疫保护机制。这将通过研究局部和系统免疫以及与疾病长期保护相关的免疫细胞的作用来实现。针对这种病毒的保护机制尚不清楚，这阻碍了有效疫苗的开发。该项目的预期结果是采取更合理的疫苗接种方法，从而产生更有效和更安全的疫苗接种战略，这将使我们重要的家禽业受益。此外，有关粘膜免疫标记物的新方法和知识可用于其他病原体的研究。

This project aims to investigate the mechanisms of immune protection against infectious laryngotracheitis virus. This will be achieved by investigating the role of local and systemic immunity and the immune cells associated with long-term protection against disease. The mechanisms of protection against this virus remain unknown which impairs the development of efficacious vaccines. Expected outcomes of this project are a more rational approach to vaccination resulting in the generation of more effective and safer vaccination strategies that should benefit our important poultry industry. Additionally, the new methodologies and knowledge on mucosal immune markers could be utilised for the study of other pathogens.