EFFECT OF ORTHODONTIC TOOTH MOVEMENT ON PERIODONTIUM

牙齿排列不良在牙周炎的病因和发展中起重要作用 牙周病。患者在练习适当的口语时有困难 在牙齿拥挤和旋转的地方保持卫生。根部贴近度 伴成细小的牙间骨会对 长期的牙周状况。创伤性咬合，结果是 牙齿或骨骼之间的差异，削弱牙周组织。 通过治疗牙周病患者的错牙合， 牙科健康的预后得到改善，因为治疗是 针对进行性骨质疏松的病因。 在开始治疗之前，必须有牢固的牙周基础 正畸牙齿移动。原始牙周组织的再生 降低因正畸而导致的有害骨丢失风险 牙齿移动并增强牙齿的稳定性 正畸定位的牙列。这两种技术的结合 血小板衍生生长因子和胰岛素样生长因子已被 可促进硬组织和软组织的愈合。互补性 这两种生长因子的作用发生在有丝分裂、细胞 新陈代谢和细胞迁移。的协同作用特性 牙周缺损修复过程中PDGF/IGF-I的相互作用 在比格犬研究中得到了深入的探索。 这项拟议的研究将阐明正畸牙齿的作用。 多肽生长对牙周组织再生的影响 各种因素。作为第一个目标，将完成一项初步研究，以评估 自然修复Beagle牙牙周组织的实验研究 正在发生的疾病。在再生后，正畸运动的 将进行牙列检查。反应的组织学检查 将对再生组织进行运动；以及 与健康牙列中发现的反应进行比较 正畸牙齿移动将完成。目标2将包括 评估再生模式和正畸治疗的反应 通过纵向射线照相的移动。顺序标准化 放射摄影术将确定再生的毫米数和 牙齿移动时这些钙化组织的维持或丢失 进步了。目标3将涉及组织标志物的分析 正畸牙移动与牙周组织的特点 再生。这些标志物包括I型、III型、XII型胶原， 骨钙素、碱性磷酸酶和酸性磷酸酶。数据 收集到的数据将用于探讨 正畸牙齿联合牙周组织再生的临床研究 有动静。 关键词：牙周组织、再生、正畸牙齿移动 比格犬，血小板衍生生长因子，胰岛素样生长因子

Malaligned teeth play a major role in the etiology and progression of periodontal disease. Patient have difficulty practicing adequate oral hygiene in areas where teeth are crowded and rotated. Root proximity with accompanying into thin interdental bone are detrimental to long-term periodontal status. Traumatic occlusion, a result of interarach dental or skeletal discrepancies, weakens the periodontium. By treating the malocclusion of a periodontally-compromised patient, the prognosis of the dental health is enhanced, since the treatment is targeted at the etiologic agent of the progressive bone loss. A firm periodontal foundation must be present prior to initiation of orthodontic tooth movement. Regeneration of the original periodontium reduces the risk of detrimental bone loss as a result of orthodontic tooth movement and enhances the stability of a orthodontically-positioned dentition. The combination of platelet-derived growth factor and insulin-like growth factor have been shown to potentiate healing of both hard and soft tissue. Complementary effects of these two growth factors occur in mitogenesis, cell metabolism, and cell migration. The synergistic properties of the PDGF/IGF-I interaction during the healing of periodontal defects have been explored intensively in beagle dog studies. The proposed study will elucidate the effects of orthodontic tooth movement on periodontium regenerated by means of a polypeptide growth factors. As a first aim, a pilot study will be completed to evaluate the regeneration of the periodontium about beagle teeth with naturally occurring disease. Following regeneration, orthodontic movement of the dentition will be performed. Histological examination of the response of the regenerated tissue to the movement will be conducted; and a comparison to the response found in healthy dentition subjected to orthodontic tooth movement will be completed. AIM 2 will consist of evaluating the pattern of regeneration and the response to orthodontic movement by longitudinal radiographs. Sequential standardized radiography will determine the millimeter amount of regeneration and maintenance or loss of these calcified tissues as tooth movement progresses. AIM 3 will involve assaying for tissue markers characteristic of orthodontic tooth movement and periodontium regeneration. This markers include Type I, III, XII collagen, ostecalcin, alkaline phosphatase, and acid phosphatase. The data collected will be used to explore the benefits and limitations of periodontium regeneration in conjunction with orthodontic tooth movement. KEYWORDS: Periodontium, Regeneration, Orthodontic tooth movement, Beagle dog, Platelet-derived growth factor, Insulin-like growth factor