ANIMAL PRODUCTION AND RESEARCH CENTER

塔夫茨大学兽医学院（TUSVM）继续 制定全面的集中实验动物计划（完全AAALAC 认证，11/89），并建立了良好的研究基础（第五最好的 国立卫生研究院资助的兽医学校）。 学校还 成为生物医学研究的主要区域资源 使用传统的农场动物，包括猪，山羊和绵羊。 因为 学校的资源，专业知识和地区，两个独特的， 不可替代的高度近交的小型猪群（6个特定的创始者 单倍型）之前由NIH（Poolesville，Md.）和 美国农业部（马里兰州贝尔茨维尔）已迁移至TUSVM）。 这些牛群是 积极管理，改善和扩大由一个既定的团队， 动物科学家、兽医和经验丰富的养猪生产人员 实验动物医学部（DLAM）。 这些动物 正在被用于许多正在进行的NIH赞助的项目， 由美国农业部内部资助的研究 其他生物技术举措包括 正在进行的生产转基因小型猪的计划， 组织相容性表面抗原显微注射与胚胎干细胞 细胞技术 动物在可用时提供给其他动物。 调查人员提出要求并支付费用。 为了适应这些 动物，学校已经修改，改进和扩大其猪 生产设施符合NIH指南的标准， 农业动物护理和使用协会指南 研究和预期新的美国农业部法规。 尽管作出了这些努力， 由于目前每年的请求，我们的设施出现了严重的压力 最多可饲养1,300头近交系小型猪和1,000头约克郡猪。 为了缓解严重的设施不足， 发病率/死亡率，专门的小型猪分娩和保育设施 将通过改造5900+总平方米建造。英尺23号楼 这 建筑物毗邻并通过一条改进的走廊连接到 皮博迪馆，目前的核心学校的DLAM和 生殖/转基因研究设施（包括动物饲养， 手术室和实验室）。 目前正在要求提供资金， 23号楼全面翻修费用的一部分， 分摊一般装修费用，购买定制 分娩和保育单元、饲料输送系统和卫生处理 设备. 此外，正在申请资金，以建造一个柴油动力的 发电机，足以为23号楼提供应急电力 小型猪设施，以及四个相邻的DLAM设施，目前 没有这项服务。

Tufts University School of Veterinary Medicine (TUSVM) is continuing to develop a comprehensive centralized laboratory animal program (fully AAALAC accredited, 11/89), and has established a sound research base (fifth best NIH funded veterinary school in the nation). The school has also established itself as a major regional resource for biomedical research using traditional farm animals, including pigs, goats and sheep. Because of the school's resources, expertise and locale, two unique and irreplaceable herds of highly inbred minipigs (6 specific founder haplotypes) previously maintained by the NIH (Poolesville, Md.) and the USDA (Beltsville, Md.) have been relocated to the TUSVM). These herds are being actively managed, improved and expanded by an established team of animal scientists, veterinarians and an experienced swine production staff within the Division of Laboratory Animal Medicine (DLAM). These animals are being utilized in numerous ongoing NIH sponsored projects and in intramurally funded USDA research. Other biotechnology initiatives include ongoing programs to produce transgenic minipigs that express human histocompatibility surface antigens using microinjection and embryonic stem cell techniques. Animals are provided, when available, to other investigators upon request and at cost. In order to accommodate these animals, the school has modified, improved and expanded its swine production facilities in compliance with the standards of the NIH Guide and the Consortium Guide for the Care and Use of Agricultural Animals in Research and anticipated new USDA regulations. Despite these efforts a severe strain on our facilities has occurred with current annual requests for up to 1,300 inbred minipigs and 1,000 Yorkshire pigs. In order to alleviate severe facilities deficiencies and minimize morbidity/mortality, a specialized minipig farrowing and nursery facility will be constructed by renovating 5900+ gross sq. ft. of Bldg 23. This structure is adjacent to and attached by an improved corridor to the Peabody Pavilion, the current core of the school's DLAM and reproduction/transgenic research facility (incorporating animal housing, surgical suites and laboratories). Funds are being requested to defray a portion of the costs for the comprehensive renovation of Bldg. 23 by sharing the cost of the general renovation, the purchase of custom farrowing and nursery units, feed delivery systems, and sanitization equipment. In addition, funds are being requested for a diesel powered generator sufficient to provide emergency electrical power for the Bldg. 23 minipig facility, as well as the four adjoining DLAM facilities currently without this service.