CAGE WASHER REPLACEMENT AND RELATED RENOVATION

詹姆斯甘布尔医学研究所(GIMR)进行动物实验 研究以支持和加强其在病毒学和 与轮状病毒、疱疹病毒相关的免疫学 创伤诱导的宿主防御机制。 自1988年以来，GIMR为其30年的历史完成了82,000美元的改进 动物设施，包括修复墙壁、地板、天花板、窗户和 门，以及建造II级生物危害，术前和非 外科手术室。进行了改进以纠正不足之处 被美国农业部引用的关于内表面和维护 遵守动物福利法规、公共卫生服务指南和 GIMR机构动物护理和使用委员会的建议 (IACUC)。 1952年，计划进行的改进包括更换已有30年历史的笼子 1989年被拆除的洗涤设备，因为它不再是 是可以修复的。自从笼子垫圈后，所有的笼子都被手动消毒了 被移除了。 目前资助的动物研究涉及感染了几种 不同的病毒病原体。因此，需要资源才能使笼子 清洁后没有交叉污染的风险。此外，经过消毒的笼子 对于动物面临更高风险的项目来说是必不可少的 感染。 该提案要求提供资金用于改建、翻新和 与这些改进相关的设备。设备包括一个新的笼子 可同时清洗平底锅和架子的垫圈、喷嘴和支架，180度 F洗涤温度保证，给料瓶洗涤系统，给料瓶 洗涤护理，水箱降温。改建和翻新包括 电力、管道和排气。

The James N. Gamble Institute of Medical Research (GIMR) performs animal studies to support and enhance its research activities in virology and immunology, related to rotaviruses, herpes viruses and the alterations of host defense mechanisms induced by trauma. Since 1988, GIMR completed $82,000 of improvements for its 30 year old animal facility, including repair of walls, floors, ceilings, windows and doors, and construction of a Level II Biohazard, pre-operative and non- surgical procedure rooms. Improvements were made to correct deficiencies cited by the U.S.D.A. with respect to interior surfaces and to maintain compliance with respect to Animal Welfare regulations, PHS guidelines and recommendations of the GIMR Institutional Animal Care and Use Committee (IACUC). In 1952, planned improvements include replacement of 30 year old cage washing equipment which was removed in 1989 because it was no longer reparable. All cages have been sanitized manually since the cage washer was removed. Currently funded animal studies involve animals infected with several different viral pathogens. Thus, resources are needed to allow cages to be cleaned without the risk of cross contamination. Further, sanitized cages are essential to projects where animals are at increased risk for infection. This proposal requests funding for the alterations, renovations and equipment related to these improvements. Equipment includes a new cage washer, jets and holders for simultaneous pan and rack washing, 180 degree F wash temperature guarantee, feeder bottle washing system, feeder bottle washing care, and cool down tank. Alterations and renovations include electric, plumbing and exhaust.