CALCIUM AND INTEGRATION IN PYRAMIDAL CELLS

描述：这是经过修订的重新提交的竞争续约申请 申请继续研究电学的离子基础 海马锥体细胞树突状细胞的光学活性 细胞内离子活度的探针。近期的实验工作 显示在突触激活过程中，许多钙离子进入是通过 钠离子刺激后激活的电压依赖性钙通道。 该提案将检查特定的突触输入和代理 影响钾通道会影响钙进入的空间范围。 强烈的突触刺激可引起树突状钙峰，而 突触输入和钾通道调节剂对突触传递的影响 将对树枝状钙尖峰进行研究。我们将努力 测定钙离子通过NMDA受体通道的内流。电压的类型- 参与钙内流的依赖性钙通道将被检测。

DESCRIPTION: This is a revised re-submission of a competitive renewal application to continue studies on the ionic basis of electrical optical activity in dendritic trees of hippocampal pyramidal cells using probes of intracellular ionic activity. Recent experimental work shows that much Ca entry during synaptic activation is through voltage-dependent Ca channels activated subsequent to Na spiking.This proposal will examine whether specific synaptic inputs and agents affecting potassium channels affect the spatial extent of Ca entry. Strong synaptic stimulation can evoke dendritic Ca spikes, and the effects of synaptic inputs and K channel modulators on propagation of dendritic Ca spikes will be studied. An effort will be made to measure Ca entry through NMDA receptor channels. The types of voltage- dependent Ca channels involved in Ca influx will be examined.