NEW THERAPEUTIC APPROACHES FOR MALIGNANT GLIOMA

恶性胶质瘤患者的治疗仍然是一种 挑战。这项研究计划的目标是开发新的 恶性胶质瘤的治疗方法。这项计划项目 由三个项目和一个核心单位组成。设计了一个项目 辐射剂量率变化对人脑胶质瘤的影响 并可能导致对最佳辐射的更好的理解 单独使用或与化疗联合使用的剂量率。一个 第二个项目探索细胞因子在导致脑水肿中的作用 以及可能的控制脑水肿的技术。第三个项目 探讨外周型苯二氮卓类受体在脑出血中的作用 恶性肿瘤的增殖、分化和细胞周期动力学 胶质瘤及其与化疗和细胞因子的潜在相互作用。 核心单位将负责建立和维护 恶性胶质瘤细胞系。此外，核心单位还将 从病人身上采集脑瘤样本，从肿瘤中分离DNA和RNA 并从患者的肿瘤中获得分子遗传学数据以及S他们的 细胞系。总而言之，这些调查可能会导致改善 恶性脑胶质瘤减容治疗的近期疗效 治疗带来的潜在神经毒性。这些项目以及 我们中心的潜在优势是发展的基础 一个脑瘤研究中心。

The treatment of patients with malignant glioma continues to be a challenge. The goal of this research program is to develop new therapeutic approaches for malignant glioma. This program project consists of three projects and one core unit. One project is designed to study the effects of variation of radiation dose rates on human glioma cells and may lead to a better understanding of the optimal radiation dose rate to use either alone or when combined with chemotherapy. A second project explores the role of cytokines in producing brain edema and possible techniques to control brain edema. The third project investigates the role of peripheral-type benzodiazepine receptors in the proliferation, differentiation, and cell cycle kinetics of malignant glioma and their potential interactions with chemotherapy and cytokines. The core unit will be responsible for establishing and maintaining malignant glioma cell lines. In addition, the core unit will also collect brain tumor samples from patients, isolate DNA and RNA from tumor and obtain molecular genetic data from patients' tumors as well s their cell lines. Together, these investigations may lead to improvement in the efficacy in current treatment for malignant glioma while reducing potential neurotoxicity from therapy. These projects along with the potential strengths of our Center form the basis for the development of a Brain Tumor Research Center.