AUTOIMMUNE PHENOMENA IN SCHIZOPHRENIA

自身免疫机制已被描述为许多中枢神经系统疾病。 系统疾病，并已提出，精神分裂症的股票 几个临床，流行病学和遗传特征与他们。 系统性狼疮等疾病的典型免疫指标异常 红斑、多发性硬化和类风湿性关节炎也被 在精神分裂症中得到证实， 精神分裂症和自身免疫发病机制。搜索的历史 然而，精神分裂症的免疫性烙印一直是一个 有争议的一个，有一些有趣的发现， 找到复制品本修订申请在小额赠款 类别是试图证明和关联异常血清和CSF 白细胞介素水平、CD 5 + B细胞增加和抗脑抗体 同一组72名住院精神分裂症患者。 将对双相情感障碍患者和健康个体进行研究， 对照血清催乳素和抗精神病药物对脑梗死患者的影响 将检查免疫措施。在修订后的提交文件中，重点是 致力于检查更大样本的患者， 精神病学对照，以扩展我们先前的发现， 研究的精神分裂症患者血清IgG抗体的60- 线粒体热休克蛋白。相关研究表明， 其他假定的自身免疫参数的具体发现将 进行。据推测，同时出现的一些这样的 精神分裂症患者同一亚组的自身免疫相关结果 这个试验项目中的患者支持自身免疫性疾病的理论， 发病机制，并为未来的研究提出了方向。

Autoimmune mechanisms have been described for a number of central nervous system diseases, and it has been suggested that schizophrenia shares several clinical, epidemiological, and genetic characteristics with them. Abnormal immunologic measures typical of diseases such as systemic lupus erythematosus, multiple sclerosis, and rheumatoid arthritis have also been demonstrated in schizophrenia and provide another indirect link between schizophrenia and an autoimmune pathogenesis. The history of the search for immunological stigmata in schizophrenia, however, has been a controversial one, with a number of intriguing findings which have failed to find replication. The present Revised Application in the SMALL GRANT category is an attempt to demonstrate and correlate aberrant serum and CSF interleukin levels, increased CD5+ B Cells, and anti-brain antibodies in the same group of seventy-two hospitalized schizophrenic patients. Patients with bipolar disorder and healthy individuals will be studied as controls. The effects of serum prolactin and neuroleptic medication on the immunologic measures will be examined. In the revised submission, focus is placed on the efforts to examine a larger sample of patients and psychiatric controls to extend our previous finding that 40% of schizophrenic patients studied had serum IgG antibodies to the 60- kilodalton PI mitochondrial heat shock protein. Studies to correlate this specific finding with other putative autoimmune parameters will be undertaken. It is hypothesized that the co-occurrence of a number of such autoimmune-associated findings in the same subgroup of schizophrenic patients in this pilot project would support a theory of autoimmune pathogenesis and would suggest directions for future research.