NORMAL AND PATHOLOGICAL BRAIN IRON

近年来，正常的和病理性的脑铁吸引了 重新引起人们的兴趣，因为人们担心一些常见的疾病，如 帕金森氏病和阿尔茨海默氏症与变化有关 在局部的铁代谢中。磁共振成像现在允许 正常脑铁在黑质中的可视化，红色 核团、齿状核和苍白球，以及 将渗出的血红蛋白铁转化为含铁血黄素。蜂窝手机 与此转换相关的事件已由 铁蛋白的免疫细胞化学和超微结构显示 小胶质细胞，以及星形胶质细胞中铁蛋白抑制蛋白的表达。在……里面 除了铁蛋白，还发现了其他携带铁的蛋白质 大脑。在这些蛋白质中，转铁蛋白作为一种 少突胶质细胞的免疫细胞化学标记物及其临床意义 少突胶质细胞在髓鞘形成过程中成熟。中风的严重性 创伤可能部分依赖于铁催化的脂质过氧化，以及 重铁蛋白的加速生物合成被认为是一种 对组织损伤的重要防御机制。尽管最近 分布和细胞定位知识的进展， 大脑中的铁仍然是一个谜。拟建的卫星 研讨会寻求将师范领域的精选专家聚集在一起 和病理性脑铁，将包括铁成像和 铁催化的脂质过氧化。会议还将解决 关于转铁蛋白及其受体在转铁蛋白中的作用的问题 流动的铁通过血脑屏障的运输， 小胶质细胞在解决出血性脑损伤中的重要性 以及生长过程中脑铁和全身铁的行为 缺乏症。

In recent years, normal and pathological brain iron have attracted renewed interest because of concern that some common disorders such as Parkinson's disease and Alzheimer's dementia are associated with changes in local iron metabolism. Magnetic resonance imaging now permits the visualization of normal brain iron in the substantia nigra, the red nuclei, the dentate nuclei, and the globus pallidus, and the stepwise conversion of extravasated hemoglobin iron to hemosiderin. The cellular events accompanying this conversion have been clarified by the immunocytochemical and ultrastructural visualization of ferritin in microglia, and of the ferritin repressor protein in astrocytes. In addition to ferritin, other iron-carrying proteins have been found in brain. Among these proteins, transferrin has become prominent as an immunocytochemical marker of oligodendroglia and as an indicator of oligodendroglial maturation during myelination. The severity of stroke and trauma may depend in part on iron-catalyzed lipid peroxidation, and the accelerated biosynthesis of heavy ferritin is thought to be an important defense mechanism against tissue injury. Despite the recent advances in the knowledge of distribution and cellular localization, brain iron continues to be quite enigmatic. The proposed satellite symposium seeks to bring together selected experts in the field of normal and pathological brain iron and will include students of iron imaging and iron-catalyzed lipid peroxidation. The conference will also resolve questions about the role of transferrin and the transferrin receptor in the transport of mobile iron across the blood brain barrier, the importance of microglia in the resolution of hemorrhagic brain lesions, and the behavior of brain iron during growth and systemic iron deficiency.