INTERNATIONAL WORKSHOP ON HUMAN CHROMOSOME 3

描述：(改编自申请者摘要)大卫·史密斯博士 请求资金支持第五届国际3号染色体 会议将于1994年5月12-13日在密歇根大学举行。 这次会议将汇集来自世界各地的40名研究人员 世界上致力于构建这两种基因连锁的人 或3号染色体的物理图谱。本研讨会的目的是 整合这些实验室产生的数据，以构建 3号染色体的高分辨率遗传连锁和物理图谱 确保协商一致的地图来自这次会议， 作为要求，参与者必须提前提交他们的数据 接受研讨会的邀请。会议的结构将是 每个相关实验室的一系列简短介绍 随后是紧张的工作会议，以解决 绘制地图，并制作共识地图。以前面临的一个主要问题是 3号染色体社区一直是每个小组一直在识别的 他们自己的标记，并在他们的基础上构建地图。当前计划 是将不同的标记整合到紧密的遗传连锁中 通过在实验室之间交换标记和使用物理地图 通用参考图书馆：(1)全人类中心 酵母人工染色体(YAC) 文库；(2)最近构建的3号染色体粘粒文库。 不同的组织目前正在分离与 它们的个体标记，并通过比较 不同的群体有不同的标记应该是可能的 将所有标记整合到遗传连锁和物理图谱中 染色体。这也将表明染色体的区域是 特征不佳的。组织者将发布一份关于这一点的报告 在两年内达成一致的遗传连锁和物理图谱 会议日期的几个月。

DESCRIPTION: (Adapted from the applicant's abstract) Dr. David Smith requests funds to support the Fifth International Chromosome 3 Conference to be held May 12-13, 1994 at the University of Michigan. This meeting will bring together 40 researchers from throughout the world who are committed to the construction of either genetic linkage or physical maps for chromosome 3. The purpose of this workshop will be to consolidate data generated by these laboratories to construct high-resolution genetic linkage and physical maps for chromosome 3. To ensure that consensus maps are derived from this meeting, the participants will have to submit their data in advance as a requirement for acceptance to the workshop. The structure of the meeting will be a series of short presentations by each of the laboratories involved followed by intense working sessions to resolve inconsistencies in the map and to produce consensus maps. A major problem previously faced by the chromosome 3 community has been that each group has been identifying their own markers and constructing maps based upon them. Current plans are to integrate the different markers into cohesive genetic linkage and physical maps by exchanging markers between laboratories and using commonly available reference libraries: (1) the total human Centre d'Etude Polymorphisme Humain (CEPH) yeast artificial chromosome (YAC) library; and (2) a recently constructed chromosome 3 cosmid library. Various groups are currently isolating large YAC clones homologous to their individual markers and by comparing YAC clones isolated by different groups with their different markers it should be possible to integrate all the markers into genetic linkage and physical maps of this chromosome. This will also indicate areas of the chromosome that are poorly characterized. The organizers will publish a report of this meeting with consensus genetic linkage and physical maps within two months of the date of the meeting.