SKELETAL MUSCLE HYDROPHOBIC PROTEOGLYCANS

这项调查的目的是允许一个合作研究， 存在骨骼肌疏水蛋白聚糖结构， 大卫凯里博士的实验室（盖辛格诊所，魏斯 宾夕法尼亚州丹维尔研究中心）和恩里克·布兰登博士的实验室 （智利天主教大学生物科学系，圣地亚哥， 智利）。 本提案的长期目标是了解 骨骼肌质膜蛋白聚糖的生物学功能。 本提案的具体目的是确定和描述 跨膜和磷脂酰肌醇连接的蛋白聚糖，并研究 疏水蛋白聚糖表达的时间过程 在肌肉分化过程中。 这些研究将补充正在进行的 凯里博士实验室里的生物化学研究 疏水蛋白聚糖的神经生物学和分子生物学， 硫酸化大分子的细胞生物学和生理学 实验室

The purpose of this investigation is to allow a collaborative study on the presence of skeletal muscle hydrophobic proteoglycan structure and function between Dr. David Carey's laboratory, (Geisinger Clinic, Weis Center for Research, Danville, PA) and Dr. Enrique Brandan's laboratory (Faculty of Biological Sciences, Catholic University of Chile, Santiago, Chile). The long term goals of this proposal are to understand the biological functions of skeletal muscle plasma membrane proteoglycans. The specific aims of this proposal are to identify and characterize transmembrane and phosphatidylinositol-linked proteoglycans and to study the time course of the expression of the hydrophobic proteoglycans during muscle differentiation. These studies will complement ongoing research in Dr. Carey's laboratory dealing with the biochemistry, neurobiology and molecular biology of hydrophobic proteoglycans, and the cell biology and physiology of sulfated macromolecules in Dr. Brandan's laboratory.