FACILITY FOR NON-HUMAN PRIMATES IN INFECTIOUS DIS RES

该计划的目标是维持非人类灵长类动物和 生物危害控制设施中的其他小动物，用于研究 选定呼吸道和肠道疾病。此外，还有许多 技术程序将在动物身上进行。测试 各种重组流感病毒，人呼吸道合胞病毒 病毒和轮状病毒将在松鼠、猫头鹰、蝙蝠、恒河猴、 还有非洲绿猴子，可能还有雪貂。 呼吸道感染的研究将特别集中在 关于候选疫苗毒株的测试，将涉及4至20个 每项研究都有动物。个别研究可能不会超过两个月 每年将进行多达8项研究。 SEMA的技术和专业人员将执行 由项目官员提供的实验方案。这将是 包括给灵长类动物接种由 项目干事，采集血液和组织样本，执行 体格检查和其他实验程序，如 探查性剖腹手术和淋巴结活检。在大多数情况下， 研究，预计SEMA将进行鼻部和喉部手术 拭子、气管灌洗、气管内接种、X光照片和 临床观察。用于典型的20只动物流感研究；20只 X光照片，20次气管接种，600次鼻咽拭子，120次 气管冲洗和100个血液样本将在28到56个月内进行 一天的时间。

The objective of this program is to maintain non-human primates and other small animals in biohazard containment facilities for studies of selected respiratory tract and enteric disease. In addition, many technical procedures will be performed on the animals. Testing of various reassortant influenza viruses, human respiratory syncytial viruses and rotaviruses will be done in squirrel, owl, patas, rhesus, and African Green monkeys, and possibly ferrets. Studies with respiratory tract infections will, particularly, be focused on testing of candidate vaccine strains and will involve from 4 to 20 animals per study. Individual studies will likely not exceed two months in duration and up to 8 studies will be performed each year. The technical and professional staff of SEMA will perform the experimental protocols as provided by the Project Officer. This will include inoculating the primates with viral material provided by the Project Officer, collecting blood and tissue samples, performing physical examinations, and other experimental procedures such as exploratory laparotomies and lymph node biopsies. For most of the studies, it is anticipated that SEMA will perform nasal and throat swabs, tracheal lavages, intratracheal inoculations, radiographs and clinical observations. For a typical 20 animal influenza study; 20 radiographs, 20 tracheal inoculations, 600 nasal and throat swabs, 120 tracheal lavages and 100 blood samples will be performed over a 28 to 56 day period.