CARE AND HOUSING OF AIDS RESEARCH ANIMALS

该项目的目标是维持非人灵长类动物在 用于研究各种生物的生物危害遏制设施 探员们。此外，许多技术程序将在 110只动物。这些生物制剂的测试将在恒河猴身上进行， 非洲绿猴，以及其他非洲、亚洲和新大陆物种 (即塔拉普猴和辫尾猴)。与司马迁一起学习 免疫缺陷病毒(SIV)将集中在滴定研究上，病毒 从不同物种分离，接种不同克隆和 病毒在动物之间的传播。预计有几个 每年都会进行研究。 SEMA的技术和专业人员将执行 由项目官员提供的实验方案。这将是 包括给灵长类动物接种由 项目干事，采集血液和组织样本，执行 体格检查和其他实验程序，如 剖腹探查和淋巴结活检。在大多数情况下， 研究表明，预计SEMA将收集脊髓液、血清、 咽喉和鼻腔拭子和粪便样本。接种应为 静脉内、腹膜内、皮下和 肌肉内。

The objective of this Project is to maintain non-human primates in biohazard containment facilities for studies of various biological agents. In addition, many technical procedures will be performed on the 110 animals. Testing these biological agents will be done in rhesus, African green monkeys, and other African, Asian and New World species (i.e. talapoin and pigtail monkeys). Studies with Simian Immunodeficiency Virus (SIV) will be focused on titration studies, virus isolation from various species, inoculation of various clones and passage of virus from animal to animal. It is anticipated that several studies will be performed each year. The technical and professional staff of SEMA will perform the experimental protocols as provided by the Project Officer. This will include inoculating the primates with viral material provided by the Project Officer, collecting blood and tissues samples, performing physical examinations, and other experimental procedures such as exploratory laparomies and lymph node biopsies. For most of the studies, it is anticipated that SEMA will collect spinal fluid, sera, throat and nasal swabs and fecal samples. Inoculations shall be performed intravenously, intraperitoneally, subcutaneously and intramuscularly.