PEDIATRIC LUNG & HEART COMPLICATIONS OF HIV INFECTION

该计划的主要目标是进一步了解艾滋病毒 婴儿和儿童感染及其对心脏疾病的影响 和肺 为此，我们将： 1. 收集有关产前过程和随后的肺 第I组：婴儿和儿童的心脏生长、发育和功能 最近确诊的、围产期传播的有症状的艾滋病毒感染者; 母亲感染艾滋病毒的新生儿 艾滋病毒感染呈阴性，但感染艾滋病毒的风险很高， 艾滋病毒 2. 确定肺部疾病的类型、发病率、病程和结局， 这些儿童的心血管疾病，并阐明病因 以及这些肺和心脏异常的病理生理学。 该计划分为三个范围： 1. 临床和实验室-招募所需数量的病人; 协调临床护理与本提案中概述的各种研究， 提供核心实验室支持， 调查的组成部分。 2. 心脏病学-确定心脏病的自然史， 儿童艾滋病病毒感染和发病率的小学和中学 围产期HIV感染儿童心脏病;早期识别 感染儿童心脏病的临床标志物;确定 实验室标志物和辅助因子， 感染的病人。 3. 肺-研究肺疾病的自然史， 感染艾滋病毒的婴儿和儿童在子宫内传播或 在围产期期间;收集有关关系的信息 艾滋病毒感染与随后的肺部生长、发育和 功能;研究病毒的作用;确定可能有助于 早期诊断和治疗。

The primary objective of the program is to further understand HIV infection in infants and children and its effects on disorders of the heart and lung. To this end we will: 1. collect information on the prenatal course and subsequent pulmonary cardiac growth, development and function of Group I: Infants and children with recently diagnosed, perinatally transmitted symptomatic HIV infection; Newborn infants of mothers infected with HIV; Newborn infants of mothers who are seronegative for HIV infection but at high risk of infection for HIV 2. determine the types, incidence, course, and outcome of pulmonary and Cardiovascular disorders in these children and to elucidate the etiology and pathophysiology of these lung and heart abnormalities. The program is separated into three scopes: 1. Clinical and Laboratory - To recruit the required number of patients; coordinate clinical care with various studies outlined in this proposal and to provide core laboratory support for infectious and immunological components of this investigation. 2. Cardiology - To determine the natural history of cardiac disease in children with HIV infection and the incidence of both primary and secondary cardiac disease in children with perinatal HIV infection; identify early clinical marker of cardiac disease in infected children; determine laboratory markers and co-factors which precipitate clinical disease in infected patients. 3. Pulmonary - To study the natural history of pulmonary disorders in infants and children infected with HIV transmitted either in utero or during the perinatal period; collect information on the relationship between HIV infection and subsequent pulmonary growth, development and function; study the role of viruses; to identify tests that might aid in early diagnosis and treatment.