META-ANALYSIS OF DRUG ABUSE TREATMENT OUTCOME STUDIES

该项目的目标是提供数据库基础设施和 实现已发布内容的量化集成所需的软件工具 药物滥用治疗结果研究。这些设施将允许健康 服务研究人员利用元分析技术获得 更清楚地了解药物滥用治疗的有效性 通过对传统叙事的研究综述来实现。 第一阶段项目将包括几项活动，旨在 建立基准荟萃分析框架，包括：(1)收集和 相关文献的摘要；(2)设计和建造一个 数据库，用于存储抽象的学习参数；(3)选择和 整合适当的统计软件；和(4)开发 定期更新和传播数据库的机制以及 关联的软件。 在这一框架的基础上，项目第二阶段将重点开展 进行各种荟萃分析，以生成治疗评估 将药物类型等协变量考虑在内的有效性， 治疗方式和客户人口统计。第三阶段 商业化活动可能包括持续维护和 还加强了药物滥用治疗结果研究数据库 作为对该方法在其他重要公共卫生领域的适应。

The goal of this project is to provide the database infrastructure and software tools necessary to enable quantitative integration of published drug abuse treatment outcome studies. These facilities will allow health services researchers to take advantage of meta-analytic techniques to gain clearer insight into drug abuse treatment effectiveness than what can be achieved through the traditional narrative research overview. The Phase I project will consist of several activities designed to establish a baseline meta-analysis framework, including: (1) collection and abstraction of the relevant literature; (2) design and construction of a database to store the abstracted study parameters; (3) selection and integration of appropriate statistical software; and (4) development of mechanisms for regular updating and dissemination of the database and associated software. Building on this framework, Phase II of the project will focus on carrying out a variety of meta-analyses in order to generate estimates of treatment effectiveness that take into account such covariates as drug type, treatment modality, and client demographics. The Phase III commercialization activities might include on-going maintenance and enhancement of the drug abuse treatment outcome research database as well as adaptation of the approach to other important public health domains.