Estimating use of tobacco and nicotine products through wastewater analysis

该项目旨在为澳大利亚公共卫生和安全部门提供一种工具，以准确衡量一般人群的烟草消费量。尿液中特定的人类生物标志物将使用非靶标方法进行鉴定，并对其药代动力学进行量化。这些新数据将填补我们在烟草消费和替代尼古丁产品的生物标志物在人群水平排泄方面的知识空白。这个项目的成果将提供可靠的、具有成本效益的烟草消费量估计数，用于基于废水的流行病学评估。这将使烟草使用的变化首次得到准确评价，并提高烟草控制措施的效力。

This project aims to equip the Australian public health and security sector with a tool to accurately measure tobacco consumption in the general population. Specific human biomarkers in urine will be identified using non-target approaches and their pharmacokinetics quantified. The new data will address critical gaps in our knowledge on the population-level excretion of biomarkers for the consumption of tobacco and alternative nicotine products. The outcomes of this project will provide reliable, cost-effective estimates of tobacco consumption for use with wastewater-based epidemiology assessments. This will enable changes in tobacco use to be accurately evaluated for the first time and improve the efficacy of tobacco control measures.