EGF RECEPTOR SIGNALING

建议于1997年9月25日至28日举行一次研讨会， 讨论作用的分子机制的目的和 表皮生长因子受体（EGFR）及其相关基因的参与 ErbB 2、ErbB 3和ErbB 4及其配体在发育和疾病中的作用。 最近的发现使这个“老”受体基因重新变得突出， 不仅在非脊椎动物中，而且在哺乳动物发育研究中。 EGFR及其相关受体蛋白之间的串扰意味着 非常复杂的信号系统和多种选择的蜂窝 应答 这次研讨会计划聚集许多主要的 这一领域的贡献者，并讨论机制和相互作用， 在不同物种中可能以同源方式起作用的基因产物， 带来与众不同的结果。 受邀演讲者将发表演讲45 15分钟的讨论时间。 其他参与者将 15分钟的口头报告（5分钟用于 讨论）或将在海报会议上发表。 谁的决定 以口头方式提交将由组委会决定。 频繁 计划安排休息和其他讨论机会。 本系列过去七次专题讨论会（六次 （其中大多数是由申请人组织的） 先前的参与者对讨论的机会进行了评价， 从这些研讨会的智力刺激作为优秀。 的数量 参与者相对较少（120-150人）， 在友好的气氛中互动。 全体发言人 选择代表广泛的科学领域，包括 生物化学、分子生物学、发育生物学和癌症生物学。 这次研讨会的一个重要方面是，它将汇集 研究人员正在广泛研究同源信号机制， 不同的有机体，以促进新的思想交流。 另一个重要 一方面是这些生长调节基因对人类癌症的重要性 参与者可能会互动，以扩大他们的发现， 潜在有用的临床应用。

DESCRIPTION: A symposium is proposed to be held September 25-28, 1997 for the purpose of discussing the molecular mechanisms of action and the involvement of epidermal growth factor receptor (EGFR), its related genes ErbB2, ErbB3 and ErbB4, and their ligands, in development and disease. Recent findings have brought this "old" receptor gene back into prominence, not only in non-vertebrate, but also in mammalian developmental studies. The crosstalk between the EGFR and its related receptor proteins implies very complex systems of signaling and multiple choices of cellular responses. This symposium is a plan to gather together many of the major contributors to this field and to discuss the mechanisms and interactions of gene products that may be acting in homologous fashion in different species, with distinctive results. The invited speakers will present lectures 45 minutes in length with 15 minutes for discussion. Other participants will make 15 minute oral presentations of their work (with 5 minutes for discussion) or will present in a poster session. The decision of who presents orally will be the decision of the organizing committee. Frequent breaks and other opportunities for discussion are planned. The results of evaluations from the past seven symposia of this series (six of which were organized by the applicant) show that the majority of the previous participants have rated the opportunities for discussion and the intellectual stimuli from these symposia as excellent. The number of participants is relatively small (120-150) and this fosters ready interactions in a friendly atmosphere. The plenary speakers have been chosen to represent a broad range of scientific fields including biochemistry, molecular biology, developmental biology, and cancer biology. An important aspect of this symposium is that it will bring together investigators who are studying homologous signaling mechanisms in widely differing organisms, to promote new exchanges of ideas. Another important aspect is the prominence of these growth-regulating genes to human cancers and the participants who might interact to broaden their findings into potentially useful clinical applications.