TRANSPORTER OF AMINO ACIDS, PEPTIDES AND MONOAMINES

该申请要求部分资金支持1997年FASEB 夏季氨基酸运输研究会议， 肽和生物活性单胺。 重点将放在：结构， 蛋白质之间共享的功能和调节方面， 跨膜转运介质。 本次FASEB会议将 1997年7月27日至8月1日，在科罗拉多的铜山， 鼓励来自不同科学背景的参与者专注于 他们在养分和溶质问题上的集体专业知识 运输 会议将包括一次主旨发言、九次 平台会议、两次海报会议、一次讲习班和一次午餐会 圆桌讨论。 我们认为一个关于运输者的会议 氨基酸、单胺和肽的合成是及时和必要的 原因如下：1. 会议严重缺乏 （小或大）致力于有机溶质转运。 2. 一直 是最近关于这些特性的新信息的爆炸， 这些载体的功能、克隆和进化导致了 鉴定几个与疾病有关的基因 运输缺陷。 3.运输科学家对此做出了贡献 生产性产出分散在许多科学学科中，然而， 所研究蛋白质具有共同的重要特性， 有限的基因家族。 此外，概念 复杂的结构和功能带来的技术问题 为有益的科学交流提供重要的共同基础。 4.一 交通科学进一步发展的主要障碍是缺乏 关于这些蛋白质结构的信息和研究。 这 会议将汇集交通运输领域的领导者和专家， 结构分析（其中一位是我们的主讲人）。 5.最后， 会议将为从事以下工作的个人提供一个机会： 不同方面的交通在不同的系统，以交流思想，集 加强合作并获得相关技术的专业知识。 年轻 将邀请研究生和博士后培训的科学家， 颁奖典礼将颁发海报及最佳海报介绍奖 旅行奖品 虽然"运输"戈登会议完全致力于 神经肽，神经传递的生理活动的小 有机溶质的子集（一个主题在会议中被广泛讨论， 世界各地的会议）完全没有会议 致力于运输。 在生产力迅速发展的时代， 是不幸的，因此申请人会议是特别 值得支持。 1997年的会议是第一个计划中的系列会议， 运输机科学家的会议 FASEB工作人员将 提供所需的行政和组织支持， 富有成效的、组织良好的会议。

This application requests partial funding to support the 1997FASEB Summer Research Conference on the Transport Of Amino Acids, Peptides And Bioactive Monoamines. Focus will be on the: structural, functional and regulatory aspects that are shared among the protein mediators of transmembrane transport. This FASEB Conference will be help at Copper Mountain, Colorado July27 - Aug. 1, 1997, to encourage participants from diverse scientific backgrounds to focus their collective expertise on the problem of nutrient and solute transport. The Conference will consist of a keynote address, nine platform sessions, two poster sessions, a workshop and a luncheon round-table discussion. We believe a focused meeting on transporters of amino acids, monoamines and peptides is both timely and essential for the follwing reasons: 1. There is a severe scarcity of conferences (small or large) devoted to organic solute transporters. 2. There has been a recent explosion of new information on the properties, funciton, cloning and evolution of these carriers that has led to the identification of several genes responsible for disease realted to transport defects. 3. Transport scientists contributing to this productive output are scattered among many scientific disciplines, yet the protein under study share important properties and are members of a limited number of gene families. Furthermore, the conceptual and technical problems posed by their complex structure and funciton provide important common ground for useful scientific exchange. 4. A major impediment to further progress in transport science is a paucity of information and research on the structure of these proteins. This Conference will bring together leaders in transport with experts in structural analysis (one of whom is our keynote speaker). 5. Finally, the conference will provide an opportunity for individuals working on different aspects of transport in diverse system to exchange ideas, set up collaborations and gain expertise in related technologies. Young scientists in graduate and postdoctoral training will be invited to present posters and the best poster presentations will be awarded travel prizes. While the "Transport" Gordon Conference is entirely devoted to neuropeptides, neurotransmission the physiological activity of a small subset of organic solutes (a subject is wll covered in conferences and meetings around the world) there is a complete absence of meeting devoted to transporters. At a time of burgeoning productivity this lack is unfortunate and therefore the applicant conference is expecially worthy of support. The Conference of 1997 is the first planned series of meetings among transporter scientists. The FASEB staff will provide the administrative and organizational support required for a fruitful, well organized meeting.